The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 209: Serine/threonine-protein kinase pim-1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
14 P06803 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI)
(4 more)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
13 O70444 (/IDA) O70444 (/IDA) P06803 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA)
(3 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
10 P06803 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
10 P06803 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
9 P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI)
Ribosomal small subunit binding GO:0043024
Interacting selectively and non-covalently with any part of the small ribosomal subunit.
9 P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI) P11309 (/IPI)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
4 P06803 (/ISO) P58750 (/ISO) P58750 (/ISO) P58750 (/ISO)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
4 P26794 (/ISS) P58750 (/ISS) P58750 (/ISS) P58750 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P06803 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P26794 (/ISS)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 P06803 (/ISO)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
1 P06803 (/ISO)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
1 P26794 (/ISS)
Ribosomal small subunit binding GO:0043024
Interacting selectively and non-covalently with any part of the small ribosomal subunit.
1 P06803 (/ISO)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
11 P06803 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA)
(1 more)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
11 O70444 (/IDA) O70444 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA)
(1 more)
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
9 P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
9 P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
9 P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
9 P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
9 P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA)
Positive regulation of cardiac muscle cell proliferation GO:0060045
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
9 P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA)
Vitamin D receptor signaling pathway GO:0070561
The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands.
9 P11309 (/IMP) P11309 (/IMP) P11309 (/IMP) P11309 (/IMP) P11309 (/IMP) P11309 (/IMP) P11309 (/IMP) P11309 (/IMP) P11309 (/IMP)
Positive regulation of cardioblast proliferation GO:1905062
Any process that activates or increases the frequency, rate or extent of cardioblast proliferation.
9 P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
7 O70444 (/ISS) O70444 (/ISS) P06803 (/ISS) P26794 (/ISS) P58750 (/ISS) P58750 (/ISS) P58750 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
6 O70444 (/ISS) O70444 (/ISS) P26794 (/ISS) P58750 (/ISS) P58750 (/ISS) P58750 (/ISS)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
5 O70444 (/ISS) O70444 (/ISS) P58750 (/ISS) P58750 (/ISS) P58750 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
4 P06803 (/ISO) P58750 (/ISO) P58750 (/ISO) P58750 (/ISO)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
4 P06803 (/ISO) P58750 (/ISO) P58750 (/ISO) P58750 (/ISO)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
4 P06803 (/ISO) P58750 (/ISO) P58750 (/ISO) P58750 (/ISO)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
3 P58750 (/ISO) P58750 (/ISO) P58750 (/ISO)
Histone phosphorylation GO:0016572
The modification of histones by addition of phosphate groups.
3 P58750 (/ISO) P58750 (/ISO) P58750 (/ISO)
Negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179
Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
3 P58750 (/IMP) P58750 (/IMP) P58750 (/IMP)
Negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179
Any process that decreases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
3 O70444 (/ISS) O70444 (/ISS) Q86V86 (/ISS)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
2 P06803 (/ISS) P26794 (/ISS)
Histone phosphorylation GO:0016572
The modification of histones by addition of phosphate groups.
2 O70444 (/IDA) O70444 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 Q9YHZ5 (/IC)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
1 Q86V86 (/IMP)
Optokinetic behavior GO:0007634
The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus.
1 Q08BC0 (/IMP)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 P06803 (/ISO)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q9YHZ5 (/NAS)
Hyaluronan metabolic process GO:0030212
The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
1 P26794 (/IEP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q86V86 (/IMP)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 P06803 (/ISO)
Positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737
Any process that activates or increases the frequency, rate or extent of CDK activity.
1 P06803 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P06803 (/IMP)
Camera-type eye morphogenesis GO:0048593
The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
1 Q08BC0 (/IMP)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
1 P06803 (/IDA)
Positive regulation of cardiac muscle cell proliferation GO:0060045
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
1 P06803 (/ISO)
Vitamin D receptor signaling pathway GO:0070561
The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands.
1 P06803 (/ISO)
Regulation of hematopoietic stem cell proliferation GO:1902033
Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation.
1 P06803 (/IDA)
Positive regulation of cardioblast proliferation GO:1905062
Any process that activates or increases the frequency, rate or extent of cardioblast proliferation.
1 P06803 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
19 A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) P11309 (/IDA)
(9 more)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
18 A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) A0A024RD25 (/IDA) P11309 (/IDA)
(8 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
9 P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS) P11309 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA) P11309 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P06803 (/ISO) P58750 (/ISO) P58750 (/ISO) P58750 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P06803 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 P06803 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P06803 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P26794 (/ISS)