The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
High mobility group box domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 66: High mobility group family

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Four-way junction DNA binding GO:0000400
Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.
5 Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
5 Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q03973 (/IPI) Q03973 (/IPI) Q03973 (/IPI) Q03973 (/IPI) Q03973 (/IPI)
DNA binding, bending GO:0008301
The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
5 Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcriptional start site selection at RNA polymerase II promoter GO:0001174
Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
5 Q03973 (/IMP) Q03973 (/IMP) Q03973 (/IMP) Q03973 (/IMP) Q03973 (/IMP)
DNA packaging GO:0006323
Any process in which DNA and associated proteins are formed into a compact, orderly structure.
5 Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA)
Regulation of transcription by RNA polymerase I GO:0006356
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I.
5 Q03973 (/IGI) Q03973 (/IGI) Q03973 (/IGI) Q03973 (/IGI) Q03973 (/IGI)
Regulation of transcription by RNA polymerase I GO:0006356
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I.
5 Q03973 (/IMP) Q03973 (/IMP) Q03973 (/IMP) Q03973 (/IMP) Q03973 (/IMP)
Chromosome condensation GO:0030261
The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
5 Q03973 (/IMP) Q03973 (/IMP) Q03973 (/IMP) Q03973 (/IMP) Q03973 (/IMP)
Regulation of ribosomal protein gene transcription by RNA polymerase II GO:0060962
Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II.
5 Q03973 (/IGI) Q03973 (/IGI) Q03973 (/IGI) Q03973 (/IGI) Q03973 (/IGI)
Regulation of ribosomal protein gene transcription by RNA polymerase II GO:0060962
Any process that modulates the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II.
5 Q03973 (/IMP) Q03973 (/IMP) Q03973 (/IMP) Q03973 (/IMP) Q03973 (/IMP)
DsDNA loop formation GO:0090579
The formation and maintenance of DNA loops that juxtapose separated regions on the same dsDNA molecule.
5 Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
5 Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA)
Small-subunit processome GO:0032040
A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
5 Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA)
RDNA heterochromatin GO:0033553
A region of heterochromatin located at the rDNA repeats in a chromosome.
5 Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA) Q03973 (/IDA)