CATH Superfamily 1.10.287.70
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 50: ATP-sensitive inward rectifier potassium channel 1...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 27 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
ATP-activated inward rectifier potassium channel activity GO:0015272
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.
|
14 |
P70673 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
(4 more) |
|
Inward rectifier potassium channel activity GO:0005242
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
|
11 |
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
(1 more) |
|
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
11 |
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
(1 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P70673 (/IPI) Q14654 (/IPI) Q61743 (/IPI) Q63664 (/IPI) |
|
ATP-activated inward rectifier potassium channel activity GO:0015272
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.
|
3 | P97794 (/ISO) P97794 (/ISO) Q61743 (/ISO) |
|
Ankyrin binding GO:0030506
Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.
|
3 | P70673 (/IPI) Q14654 (/IPI) Q61743 (/IPI) |
|
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
|
2 | E9QD88 (/IDA) Q5R205 (/IDA) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
2 | Q61743 (/IDA) Q63664 (/IDA) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
2 | P97794 (/ISO) P97794 (/ISO) |
|
Sulfonylurea receptor binding GO:0017098
Interacting selectively and non-covalently with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel.
|
2 | P97794 (/ISO) P97794 (/ISO) |
|
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
2 | P97794 (/ISO) P97794 (/ISO) |
|
Voltage-gated potassium channel activity GO:0005249
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
1 | Q14654 (/IDA) |
|
Voltage-gated potassium channel activity GO:0005249
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
|
1 | Q61743 (/ISO) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q14654 (/ISS) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q14654 (/TAS) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | P70673 (/IPI) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | Q61743 (/ISO) |
|
ATP-activated inward rectifier potassium channel activity GO:0015272
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.
|
1 | P70673 (/IMP) |
|
ATP-activated inward rectifier potassium channel activity GO:0015272
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.
|
1 | Q14654 (/ISS) |
|
Sulfonylurea receptor binding GO:0017098
Interacting selectively and non-covalently with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel.
|
1 | Q63664 (/IPI) |
|
Ankyrin binding GO:0030506
Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.
|
1 | Q61743 (/ISO) |
|
Potassium ion binding GO:0030955
Interacting selectively and non-covalently with potassium (K+) ions.
|
1 | Q61743 (/IC) |
|
Potassium ion binding GO:0030955
Interacting selectively and non-covalently with potassium (K+) ions.
|
1 | Q14654 (/TAS) |
|
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
|
1 | P70673 (/IPI) |
|
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
|
1 | Q61743 (/ISO) |
|
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
|
1 | Q14654 (/IPI) |
|
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
|
1 | Q61743 (/ISO) |
There are 46 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
|
13 |
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
Q15842 (/IDA)
(3 more) |
|
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
11 |
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
(1 more) |
|
Membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915
The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
|
11 |
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
Q15842 (/IMP)
(1 more) |
|
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | P97794 (/ISO) P97794 (/ISO) Q61743 (/ISO) |
|
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P70673 (/IDA) Q63664 (/IDA) |
|
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P70673 (/IMP) Q63664 (/IMP) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
2 | P97794 (/IMP) P97794 (/IMP) |
|
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
2 | P97794 (/IMP) P97794 (/IMP) |
|
Response to exogenous dsRNA GO:0043330
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
|
2 | P97794 (/IMP) P97794 (/IMP) |
|
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
2 | P97794 (/IMP) P97794 (/IMP) |
|
Membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915
The process in which ions are transported across a membrane such that the ventricular cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
|
2 | P97794 (/ISO) P97794 (/ISO) |
|
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
|
2 | P97794 (/ISO) P97794 (/ISO) |
|
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
|
1 | Q63664 (/IEP) |
|
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
|
1 | P70673 (/IEP) |
|
Type B pancreatic cell development GO:0003323
The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.
|
1 | Q2HX26 (/IMP) |
|
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
|
1 | Q14654 (/IMP) |
|
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
|
1 | Q61743 (/ISO) |
|
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
|
1 | Q2HX26 (/IMP) |
|
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
|
1 | P70673 (/IEP) |
|
Response to ATP GO:0033198
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
|
1 | Q14654 (/IDA) |
|
Response to ATP GO:0033198
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
|
1 | Q61743 (/ISO) |
|
Response to testosterone GO:0033574
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
|
1 | P70673 (/IEP) |
|
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
1 | Q14654 (/IDA) |
|
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
1 | Q61743 (/ISO) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | P70673 (/IEP) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | Q14654 (/IMP) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | Q61743 (/ISO) |
|
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
|
1 | Q14654 (/IMP) |
|
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
|
1 | Q61743 (/ISO) |
|
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
|
1 | Q14654 (/IMP) |
|
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
|
1 | Q61743 (/ISO) |
|
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
|
1 | Q14654 (/TAS) |
|
Nervous system process GO:0050877
A organ system process carried out by any of the organs or tissues of neurological system.
|
1 | Q14654 (/IMP) |
|
Nervous system process GO:0050877
A organ system process carried out by any of the organs or tissues of neurological system.
|
1 | Q61743 (/ISO) |
|
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
|
1 | Q14654 (/TAS) |
|
Cellular response to nicotine GO:0071316
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.
|
1 | P70673 (/IEP) |
|
Cellular response to glucose stimulus GO:0071333
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
|
1 | P70673 (/IEP) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
1 | P70673 (/IEP) |
|
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
|
1 | Q14654 (/IDA) |
|
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
|
1 | Q61743 (/ISO) |
|
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
|
1 | P70673 (/IMP) |
|
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
|
1 | Q61743 (/ISO) |
|
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
|
1 | Q14654 (/TAS) |
|
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
|
1 | Q14654 (/ISS) |
|
Positive regulation of cation channel activity GO:2001259
Any process that activates or increases the frequency, rate or extent of cation channel activity.
|
1 | P70673 (/IMP) |
|
Positive regulation of cation channel activity GO:2001259
Any process that activates or increases the frequency, rate or extent of cation channel activity.
|
1 | Q61743 (/ISO) |
There are 41 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
12 |
Q14654 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
(2 more) |
|
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
|
11 |
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
Q15842 (/TAS)
(1 more) |
|
Inward rectifying potassium channel GO:0008282
A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity.
|
4 | P70673 (/IDA) Q14654 (/IDA) Q61743 (/IDA) Q63664 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
3 | P97794 (/ISO) P97794 (/ISO) Q61743 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P70673 (/IDA) Q14654 (/IDA) Q61743 (/IDA) |
|
Inward rectifying potassium channel GO:0008282
A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity.
|
3 | P97794 (/ISO) P97794 (/ISO) Q61743 (/ISO) |
|
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
|
3 | P97794 (/ISO) P97794 (/ISO) Q61743 (/ISO) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
3 | P97794 (/ISO) P97794 (/ISO) Q61743 (/ISO) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P70673 (/IDA) Q63664 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | E9QD88 (/IPI) Q5R205 (/IPI) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | P97794 (/ISO) P97794 (/ISO) |
|
Myofibril GO:0030016
The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.
|
2 | P97794 (/IDA) P97794 (/IDA) |
|
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
|
2 | P70673 (/IDA) Q61743 (/IDA) |
|
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
|
2 | P70673 (/IDA) Q63664 (/IDA) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | P70673 (/IDA) Q63664 (/IDA) |
|
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
|
1 | P70673 (/IDA) |
|
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
|
1 | Q61743 (/ISO) |
|
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
1 | P70673 (/IDA) |
|
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
1 | Q61743 (/ISO) |
|
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
1 | P70673 (/IDA) |
|
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
1 | Q61743 (/ISO) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | P70673 (/IDA) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | Q61743 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P70673 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
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1 | Q61743 (/ISO) |
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Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
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1 | Q61743 (/ISO) |
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Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
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1 | Q14654 (/TAS) |
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Inward rectifying potassium channel GO:0008282
A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity.
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1 | Q14654 (/ISS) |
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Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
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1 | P70673 (/IDA) |
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Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
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1 | Q61743 (/ISO) |
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Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
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1 | Q63664 (/IDA) |
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T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
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1 | Q61743 (/ISO) |
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T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
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1 | Q14654 (/ISS) |
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Axolemma GO:0030673
The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness.
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1 | P70673 (/IDA) |
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Axolemma GO:0030673
The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness.
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1 | Q61743 (/ISO) |
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Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
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1 | P70673 (/IDA) |
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Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
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1 | Q61743 (/ISO) |
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Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
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1 | P70673 (/IDA) |
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Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
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1 | Q61743 (/ISO) |
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Cell body fiber GO:0070852
A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.
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1 | P70673 (/IDA) |
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Cell body fiber GO:0070852
A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches.
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1 | Q61743 (/ISO) |