The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 73: calcineurin B-like protein 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
17 O81223 (/ISS) O81223 (/ISS) O81223 (/ISS) O81445 (/ISS) O81445 (/ISS) Q7FZF1 (/ISS) Q8LAS7 (/ISS) Q8LEM7 (/ISS) Q8LEM7 (/ISS) Q8LEM7 (/ISS)
(7 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 O81223 (/IPI) O81223 (/IPI) O81223 (/IPI) O81445 (/IPI) O81445 (/IPI) Q7FRS8 (/IPI) Q7FRS8 (/IPI) Q8L7F6 (/IPI) Q8LAS7 (/IPI) Q8LEM7 (/IPI)
(3 more)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
7 O81445 (/IPI) O81445 (/IPI) Q8LAS7 (/IPI) Q8LEM7 (/IPI) Q8LEM7 (/IPI) Q8LEM7 (/IPI) Q9LTB8 (/IPI)
Calcium-dependent protein serine/threonine phosphatase activity GO:0004723
Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions.
3 O81223 (/ISS) O81223 (/ISS) O81223 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 Q7FRS8 (/IDA) Q7FRS8 (/IDA) Q8T893 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q9D3N2 (/ISO)
Dynein heavy chain binding GO:0045504
Interacting selectively and non-covalently with a heavy chain of the dynein complex.
1 Q8T893 (/IDA)
Dynein heavy chain binding GO:0045504
Interacting selectively and non-covalently with a heavy chain of the dynein complex.
1 Q9D3N2 (/ISO)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
1 Q8T893 (/IDA)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
1 Q9D3N2 (/ISO)
Calcium-dependent outer dynein arm binding GO:0120152
Interacting selectively and non-covalently with an outer dynein arm in the presence of calcium.
1 Q8T893 (/IDA)
Calcium-dependent outer dynein arm binding GO:0120152
Interacting selectively and non-covalently with an outer dynein arm in the presence of calcium.
1 Q9D3N2 (/ISO)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
7 O81445 (/TAS) O81445 (/TAS) Q7FZF1 (/TAS) Q8LAS7 (/TAS) Q9FUQ7 (/TAS) Q9FUQ7 (/TAS) Q9FUQ7 (/TAS)
Detection of calcium ion GO:0005513
The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.
5 Q8LEM7 (/ISS) Q8LEM7 (/ISS) Q8LEM7 (/ISS) Q9SUA6 (/ISS) Q9SUA6 (/ISS)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
4 O81445 (/IMP) O81445 (/IMP) Q7FZF1 (/IMP) Q9LTB8 (/IMP)
Potassium ion homeostasis GO:0055075
Any process involved in the maintenance of an internal steady state of potassium ions within an organism or cell.
4 Q8LAS7 (/IMP) Q8LEM7 (/IMP) Q8LEM7 (/IMP) Q8LEM7 (/IMP)
Detection of calcium ion GO:0005513
The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.
3 O81223 (/IMP) O81223 (/IMP) O81223 (/IMP)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
3 O81445 (/IMP) O81445 (/IMP) Q7FZF1 (/IMP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
3 O81445 (/IMP) O81445 (/IMP) Q7FZF1 (/IMP)
Pollen tube growth GO:0009860
Growth of pollen via tip extension of the intine wall.
3 O81445 (/IMP) O81445 (/IMP) Q9LTB8 (/IMP)
Cellular potassium ion homeostasis GO:0030007
Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
3 O81223 (/IMP) O81223 (/IMP) O81223 (/IMP)
Hypotonic salinity response GO:0042539
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
3 O81223 (/IMP) O81223 (/IMP) O81223 (/IMP)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
2 O81445 (/TAS) O81445 (/TAS)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
2 O81445 (/IEP) O81445 (/IEP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
2 O81445 (/IEP) O81445 (/IEP)
Abscisic acid-activated signaling pathway GO:0009738
A series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription.
2 O81445 (/TAS) O81445 (/TAS)
Hyperosmotic salinity response GO:0042538
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
2 Q7FRS8 (/IMP) Q7FRS8 (/IMP)
Regulation of potassium ion transport GO:0043266
Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q7FRS8 (/IMP) Q7FRS8 (/IMP)
Ion homeostasis GO:0050801
Any process involved in the maintenance of an internal steady state of ions within an organism or cell.
2 Q7FRS8 (/IMP) Q7FRS8 (/IMP)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
1 Q9C5P6 (/ISS)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q8T893 (/IMP)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q9D3N2 (/ISO)
Regulation of flagellated sperm motility GO:1901317
Any process that modulates the frequency, rate or extent of flagellated sperm motility.
1 Q8T893 (/IMP)
Regulation of flagellated sperm motility GO:1901317
Any process that modulates the frequency, rate or extent of flagellated sperm motility.
1 Q9D3N2 (/ISO)
Negative regulation of ATP-dependent microtubule motor activity, minus-end-directed GO:2000578
Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed.
1 Q8T893 (/IDA)
Negative regulation of ATP-dependent microtubule motor activity, minus-end-directed GO:2000578
Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed.
1 Q9D3N2 (/ISO)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 O81223 (/IDA) O81223 (/IDA) O81223 (/IDA) O81445 (/IDA) O81445 (/IDA) Q7FRS8 (/IDA) Q7FRS8 (/IDA) Q9LTB8 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 O81445 (/IDA) O81445 (/IDA) Q7FRS8 (/IDA) Q7FRS8 (/IDA) Q8LEM7 (/IDA) Q8LEM7 (/IDA) Q8LEM7 (/IDA) Q9LTB8 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
7 Q8LAS7 (/IDA) Q8LEM7 (/IDA) Q8LEM7 (/IDA) Q8LEM7 (/IDA) Q9FUQ7 (/IDA) Q9FUQ7 (/IDA) Q9FUQ7 (/IDA)
Plant-type vacuole membrane GO:0009705
The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana.
6 Q7FRS8 (/IDA) Q7FRS8 (/IDA) Q8LAS7 (/IDA) Q8LEM7 (/IDA) Q8LEM7 (/IDA) Q8LEM7 (/IDA)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
4 Q8LAS7 (/IDA) Q8LEM7 (/IDA) Q8LEM7 (/IDA) Q8LEM7 (/IDA)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
3 Q8LEM7 (/IDA) Q8LEM7 (/IDA) Q8LEM7 (/IDA)
Calcineurin complex GO:0005955
A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.
3 O81223 (/ISS) O81223 (/ISS) O81223 (/ISS)
Pollen tube GO:0090406
A tubular cell projection that is part of a pollen tube cell and extends from a pollen grain.
2 O81445 (/IDA) O81445 (/IDA)
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
1 Q8T893 (/IDA)
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
1 Q9D3N2 (/ISO)
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
1 Q8LAS7 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q86JE1 (/HDA)
9+2 motile cilium GO:0097729
A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).
1 Q8T893 (/IDA)
9+2 motile cilium GO:0097729
A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).
1 Q9D3N2 (/ISO)