The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Annexin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 5: Annexin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 31 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
16 P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P48037 (/IDA) P48037 (/IDA)
(6 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
12 P08133 (/IPI) P08133 (/IPI) P08133 (/IPI) P08133 (/IPI) P08133 (/IPI) P08133 (/IPI) P08133 (/IPI) P08133 (/IPI) P48037 (/IPI) P48037 (/IPI)
(2 more)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
12 P08133 (/IPI) P08133 (/IPI) P08133 (/IPI) P08133 (/IPI) P08133 (/IPI) P08133 (/IPI) P08133 (/IPI) P08133 (/IPI) P79134 (/IPI) P79134 (/IPI)
(2 more)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
8 P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
8 P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP)
Ligand-gated ion channel activity GO:0015276
Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
8 P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP)
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
8 P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
8 P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
4 P79134 (/IPI) P79134 (/IPI) P79134 (/IPI) P79134 (/IPI)
Calcium channel activity GO:0005262
Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
4 P79134 (/IMP) P79134 (/IMP) P79134 (/IMP) P79134 (/IMP)
Calcium channel activity GO:0005262
Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
4 P51901 (/TAS) P51901 (/TAS) P51901 (/TAS) P51901 (/TAS)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
4 P48037 (/TAS) P48037 (/TAS) P48037 (/TAS) P48037 (/TAS)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
4 P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Ligand-gated ion channel activity GO:0015276
Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Calcium-release channel activity GO:0015278
Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
4 M3VH45 (/TAS) M3VH45 (/TAS) M3VH45 (/TAS) M3VH45 (/TAS)
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
4 P79134 (/IPI) P79134 (/IPI) P79134 (/IPI) P79134 (/IPI)
Chondroitin sulfate binding GO:0035374
Interacting selectively and non-covalently with chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc).
4 P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA)
Cargo receptor activity GO:0038024
Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.
4 P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 P79134 (/IMP) P79134 (/IMP) P79134 (/IMP) P79134 (/IMP)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 P79134 (/IPI) P79134 (/IPI) P79134 (/IPI) P79134 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
4 P48037 (/IPI) P48037 (/IPI) P48037 (/IPI) P48037 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
4 P79134 (/IPI) P79134 (/IPI) P79134 (/IPI) P79134 (/IPI)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q92108 (/ISS)
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
1 Q92108 (/ISS)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane repair GO:0001778
The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.
18 A8KBY8 (/IMP) A8KBY8 (/IMP) A8KBY8 (/IMP) A8KBY8 (/IMP) F1QSK0 (/IMP) F1QSK0 (/IMP) F1R6N3 (/IMP) F1R6N3 (/IMP) F1R6N3 (/IMP) F6IA10 (/IMP)
(8 more)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
8 P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
8 P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP) P08133 (/IMP)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
4 P51901 (/IMP) P51901 (/IMP) P51901 (/IMP) P51901 (/IMP)
Growth plate cartilage chondrocyte differentiation GO:0003418
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage.
4 P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P14824 (/IMP) P14824 (/IMP) P14824 (/IMP) P14824 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P79134 (/ISS) P79134 (/ISS) P79134 (/ISS) P79134 (/ISS)
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
4 P14824 (/IMP) P14824 (/IMP) P14824 (/IMP) P14824 (/IMP)
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
4 P79134 (/ISS) P79134 (/ISS) P79134 (/ISS) P79134 (/ISS)
Biomineral tissue development GO:0031214
Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.
4 P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Secretion GO:0046903
The controlled release of a substance by a cell or a tissue.
4 P48037 (/TAS) P48037 (/TAS) P48037 (/TAS) P48037 (/TAS)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Negative regulation of sequestering of calcium ion GO:0051283
Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.
4 P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA)
Mitochondrial calcium ion homeostasis GO:0051560
Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
4 P14824 (/IMP) P14824 (/IMP) P14824 (/IMP) P14824 (/IMP)
Calcium ion homeostasis GO:0055074
Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.
4 P51901 (/TAS) P51901 (/TAS) P51901 (/TAS) P51901 (/TAS)
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
4 P79134 (/IMP) P79134 (/IMP) P79134 (/IMP) P79134 (/IMP)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
4 P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA)
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
4 P14824 (/IMP) P14824 (/IMP) P14824 (/IMP) P14824 (/IMP)
Monocyte chemotaxis GO:0002548
The movement of a monocyte in response to an external stimulus.
1 Q92108 (/ISS)
Regulation of leukocyte migration GO:0002685
Any process that modulates the frequency, rate, or extent of leukocyte migration.
1 Q92108 (/ISS)
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
1 Q8W4Z7 (/TAS)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 Q92108 (/ISS)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
1 Q92108 (/ISS)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
1 Q92108 (/ISS)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
1 Q92108 (/ISS)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q92108 (/ISS)
Regulation of interleukin-1 production GO:0032652
Any process that modulates the frequency, rate, or extent of interleukin-1 production.
1 Q92108 (/ISS)
Positive regulation of interleukin-2 production GO:0032743
Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
1 Q92108 (/ISS)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
1 Q92108 (/ISS)
Positive regulation of T-helper 1 cell differentiation GO:0045627
Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation.
1 Q92108 (/ISS)
Negative regulation of T-helper 2 cell differentiation GO:0045629
Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.
1 Q92108 (/ISS)
Negative regulation of exocytosis GO:0045920
Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.
1 Q92108 (/ISS)
Regulation of hormone secretion GO:0046883
Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.
1 Q92108 (/ISS)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
1 Q92108 (/ISS)
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 Q92108 (/ISS)
Granulocyte chemotaxis GO:0071621
The movement of a granulocyte in response to an external stimulus.
1 Q92108 (/ISS)
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
1 Q92108 (/ISS)
Seed trichome differentiation GO:0090376
The process in which a relatively unspecialized epidermal cell acquires the specialized features of a seed trichome. A seed trichome is a trichome that develops from seed coat epidermis and is often long with putative dispersal function.
1 Q8W4Z7 (/IEP)
Seed trichome elongation GO:0090378
The process in which a seed trichome irreversibly increases in size in one
1 A6MUT1 (/IEP)
Regulation of cell motility GO:2000145
Any process that modulates the frequency, rate or extent of cell motility.
1 O57570 (/IGI)

There are 46 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
15 D6RAZ8 (/IDA) D6RCA8 (/IDA) D6RCA8 (/IDA) D6RFG5 (/IDA) D6RFG5 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) Q5T3N0 (/IDA)
(5 more)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
12 P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P14824 (/HDA) P14824 (/HDA)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
10 P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) Q5T3N0 (/IDA) Q5T3N0 (/IDA) Q5T3N1 (/IDA) Q5T3N1 (/IDA) Q5T3N1 (/IDA) Q5T3N1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 O57570 (/IDA) P48037 (/IDA) P48037 (/IDA) P48037 (/IDA) P48037 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
8 P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
8 P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
8 P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
8 P48037 (/IDA) P48037 (/IDA) P48037 (/IDA) P48037 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA)
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
8 P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA) P08133 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
8 P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA) P08133 (/HDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 Q5T3N0 (/IDA) Q5T3N0 (/IDA) Q5T3N1 (/IDA) Q5T3N1 (/IDA) Q5T3N1 (/IDA) Q5T3N1 (/IDA)
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
4 P79134 (/IMP) P79134 (/IMP) P79134 (/IMP) P79134 (/IMP)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P48037 (/IDA) P48037 (/IDA) P48037 (/IDA) P48037 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P14824 (/TAS) P14824 (/TAS) P14824 (/TAS) P14824 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
4 P79134 (/IMP) P79134 (/IMP) P79134 (/IMP) P79134 (/IMP)
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
4 P48037 (/IDA) P48037 (/IDA) P48037 (/IDA) P48037 (/IDA)
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P79134 (/TAS) P79134 (/TAS) P79134 (/TAS) P79134 (/TAS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
4 P48037 (/IDA) P48037 (/IDA) P48037 (/IDA) P48037 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Mitochondrial crista GO:0030061
Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.
4 P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA)
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
4 P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
4 P51901 (/TAS) P51901 (/TAS) P51901 (/TAS) P51901 (/TAS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
4 P48037 (/IDA) P48037 (/IDA) P48037 (/IDA) P48037 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Calcium channel complex GO:0034704
An ion channel complex through which calcium ions pass.
4 P51901 (/TAS) P51901 (/TAS) P51901 (/TAS) P51901 (/TAS)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
4 P48037 (/IDA) P48037 (/IDA) P48037 (/IDA) P48037 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
4 P14824 (/ISO) P14824 (/ISO) P14824 (/ISO) P14824 (/ISO)
Chromaffin granule membrane GO:0042584
The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.
4 P79134 (/IDA) P79134 (/IDA) P79134 (/IDA) P79134 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 P14824 (/IDA) P14824 (/IDA) P14824 (/IDA) P14824 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 P79134 (/ISS) P79134 (/ISS) P79134 (/ISS) P79134 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q92108 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q92108 (/ISS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q92108 (/ISS)
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
1 Q92108 (/ISS)
Extrinsic component of external side of plasma membrane GO:0031232
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.
1 Q92108 (/ISS)
Extrinsic component of endosome membrane GO:0031313
The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q92108 (/ISS)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
1 Q92108 (/ISS)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
1 Q92108 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q92108 (/ISS)