The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Annexin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Annexin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 99 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
57 A9JTC0 (/IPI) P04083 (/IPI) P04083 (/IPI) P04083 (/IPI) P04083 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI)
(47 more)
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
40 G5EEA8 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(30 more)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
30 P04083 (/IPI) P04083 (/IPI) P04083 (/IPI) P04083 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI)
(20 more)
Phospholipase A2 inhibitor activity GO:0019834
Stops, prevents or reduces the activity of the enzyme phospholipase A2.
20 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P07150 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(10 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
19 P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA)
(9 more)
S100 protein binding GO:0044548
Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS.
19 P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI)
(9 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
18 P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI)
(8 more)
Cadherin binding involved in cell-cell adhesion GO:0098641
Any cadherin binding that occurs as part of the process of cell-cell adhesion.
18 P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA)
(8 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
17 A5A6M2 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS)
(7 more)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
14 P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI) P07355 (/IPI)
(4 more)
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
14 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P22464 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(4 more)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
14 P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP)
(4 more)
Molecular function regulator GO:0098772
A molecular function that modulates the activity of a gene product or complex. Examples include enzyme regulators and channel regulators.
14 P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(4 more)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
10 P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS)
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
10 O35639 (/ISO) O35640 (/ISO) P07356 (/ISO) P07356 (/ISO) P10107 (/ISO) P10107 (/ISO) P14824 (/ISO) P48036 (/ISO) P97429 (/ISO) Q07076 (/ISO)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
9 O35639 (/ISO) P07356 (/ISO) P07356 (/ISO) P10107 (/ISO) P10107 (/ISO) P14824 (/ISO) P97384 (/ISO) P97429 (/ISO) Q07076 (/ISO)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
6 G5EEA8 (/IDA) P24639 (/IDA) P27216 (/IDA) P81287 (/IDA) Q27512 (/IDA) Q7JMT5 (/IDA)
Phospholipase inhibitor activity GO:0004859
Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid.
6 P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
6 G5EEA8 (/IDA) P13214 (/IDA) P79134 (/IDA) P81287 (/IDA) Q27512 (/IDA) Q7JMT5 (/IDA)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
5 P04272 (/IPI) P04272 (/IPI) P04272 (/IPI) P04272 (/IPI) P79134 (/IPI)
Calcium channel activity GO:0005262
Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
5 P04272 (/IMP) P04272 (/IMP) P04272 (/IMP) P04272 (/IMP) P79134 (/IMP)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
5 P09525 (/IDA) P13928 (/IDA) P19619 (/IDA) P27216 (/IDA) P97384 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
5 P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) Q07936 (/TAS)
Phospholipase A2 inhibitor activity GO:0019834
Stops, prevents or reduces the activity of the enzyme phospholipase A2.
5 O35639 (/ISO) P07356 (/ISO) P07356 (/ISO) P10107 (/ISO) P10107 (/ISO)
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
4 P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P04083 (/TAS)
Calcium channel activity GO:0005262
Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
4 P17153 (/TAS) P17785 (/TAS) P17785 (/TAS) P51901 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P04272 (/TAS) P04272 (/TAS) P04272 (/TAS) P04272 (/TAS)
Phosphatidylethanolamine binding GO:0008429
Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.
4 G5EEA8 (/IDA) P97384 (/IDA) Q27512 (/IDA) Q7JMT5 (/IDA)
MHC class II protein complex binding GO:0023026
Interacting selectively and non-covalently with the class II major histocompatibility complex.
4 P50995 (/HDA) P50995 (/HDA) P50995 (/HDA) P50995 (/HDA)
1-phosphatidylinositol binding GO:0005545
Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
3 G5EEA8 (/IDA) Q27512 (/IDA) Q7JMT5 (/IDA)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
3 O35640 (/ISO) P07356 (/ISO) P07356 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 P13214 (/IMP) P20072 (/IMP) P79134 (/IMP)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 P07356 (/ISO) P07356 (/ISO) P97429 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 P10107 (/ISO) P10107 (/ISO) P14824 (/ISO)
S100 protein binding GO:0044548
Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS.
3 P07356 (/ISO) P07356 (/ISO) P97384 (/ISO)
S100 protein binding GO:0044548
Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS.
3 P27214 (/ISS) P33477 (/ISS) P97384 (/ISS)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 P07356 (/ISO) P07356 (/ISO)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
2 P10107 (/ISO) P10107 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 O35640 (/ISO) P97429 (/ISO)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
2 P08133 (/IMP) P08133 (/IMP)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
2 P10107 (/ISO) P10107 (/ISO)
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
2 P07150 (/TAS) P48037 (/TAS)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
2 P13928 (/IDA) Q07936 (/IDA)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
2 P08133 (/IMP) P08133 (/IMP)
Ligand-gated ion channel activity GO:0015276
Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
2 P08133 (/IMP) P08133 (/IMP)
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
2 P08133 (/IDA) P08133 (/IDA)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
2 P07356 (/ISO) P07356 (/ISO)
Chondroitin sulfate binding GO:0035374
Interacting selectively and non-covalently with chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc).
2 P13214 (/IDA) P79134 (/IDA)
Double-stranded DNA helicase activity GO:0036121
Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix.
2 P10107 (/ISO) P10107 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P08133 (/IMP) P08133 (/IMP)
Heparan sulfate proteoglycan binding GO:0043395
Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
2 Q27512 (/IDA) Q7JMT5 (/IDA)
Bone sialoprotein binding GO:0044730
Interacting selectively and non-covalently with a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin.
2 P07356 (/ISO) P07356 (/ISO)
Virion binding GO:0046790
Interacting selectively and non-covalently with a virion, either by binding to components of the capsid or the viral envelope.
2 P17785 (/IDA) P17785 (/IDA)
Molecular function regulator GO:0098772
A molecular function that modulates the activity of a gene product or complex. Examples include enzyme regulators and channel regulators.
2 P07356 (/ISO) P07356 (/ISO)
Voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels GO:0099511
Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel.
2 P17785 (/IDA) P17785 (/IDA)
Voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels GO:0099511
Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel.
2 P17785 (/TAS) P17785 (/TAS)
DNA/DNA annealing activity GO:1990814
A nucleic acid binding activity that brings together complementary sequences of ssDNA so that they pair by hydrogen bonds to form a double-stranded DNA.
2 P10107 (/ISO) P10107 (/ISO)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
1 Q99JG3 (/ISO)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
1 P07150 (/IDA)
Phospholipase inhibitor activity GO:0004859
Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid.
1 P09525 (/NAS)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 P20073 (/IPI)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q07076 (/ISO)
Calcium transmembrane transporter activity, phosphorylative mechanism GO:0005388
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans).
1 P14668 (/IDA)
Calcium transmembrane transporter activity, phosphorylative mechanism GO:0005388
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans).
1 P48036 (/ISO)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 P14824 (/ISO)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 P07150 (/IDA)
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
1 P14668 (/IMP)
Calcium-dependent phospholipid binding GO:0005544
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium.
1 P09525 (/NAS)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
1 P13928 (/IDA)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
1 O35640 (/ISO)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
1 P14824 (/ISO)
Ligand-gated ion channel activity GO:0015276
Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
1 P14824 (/ISO)
Calcium-release channel activity GO:0015278
Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts.
1 M3VH45 (/TAS)
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
1 P14824 (/ISO)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
1 P14668 (/IDA)
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
1 P48036 (/ISO)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 Q07936 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P79134 (/IPI)
Carbohydrate binding GO:0030246
Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
1 P13214 (/TAS)
Spectrin binding GO:0030507
Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.
1 P22464 (/IPI)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
1 P14668 (/IPI)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
1 P48036 (/ISO)
Cargo receptor activity GO:0038024
Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.
1 P79134 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P07150 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P24639 (/TAS)
Phosphatidylinositol-3,4-bisphosphate binding GO:0043325
Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
1 P13928 (/IDA)
Phosphatidylinositol-3,4-bisphosphate binding GO:0043325
Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
1 O35640 (/ISO)
Bone sialoprotein binding GO:0044730
Interacting selectively and non-covalently with a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin.
1 Q07936 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P48037 (/IPI)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P14824 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 P13928 (/IDA)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 P79134 (/IPI)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 O35640 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q07936 (/TAS)
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
1 P09525 (/IPI)
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
1 P97429 (/ISO)
Phosphatidylglycerol binding GO:1901611
Interacting selectively and non-covalently with phosphatidylglycerol.
1 P27216 (/IDA)
Phosphatidylglycerol binding GO:1901611
Interacting selectively and non-covalently with phosphatidylglycerol.
1 Q99JG3 (/ISO)
DNA/DNA annealing activity GO:1990814
A nucleic acid binding activity that brings together complementary sequences of ssDNA so that they pair by hydrogen bonds to form a double-stranded DNA.
1 P07150 (/IDA)

There are 264 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of vesicle fusion GO:0031340
Any process that activates or increases the frequency, rate or extent of vesicle fusion.
18 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(8 more)
Positive regulation of low-density lipoprotein receptor activity GO:1905599
Any process that activates or increases the frequency, rate or extent of low-density lipoprotein receptor activity.
16 P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP)
(6 more)
Regulation of leukocyte migration GO:0002685
Any process that modulates the frequency, rate, or extent of leukocyte migration.
15 A5A6M2 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P07150 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS)
(5 more)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
15 A5A6M2 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P07150 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS)
(5 more)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
15 A5A6M2 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P07150 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS)
(5 more)
Regulation of interleukin-1 production GO:0032652
Any process that modulates the frequency, rate, or extent of interleukin-1 production.
15 A5A6M2 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P07150 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS)
(5 more)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
15 A5A6M2 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P07150 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS)
(5 more)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
14 P07355 (/IEP) P07355 (/IEP) P07355 (/IEP) P07355 (/IEP) P07355 (/IEP) P07355 (/IEP) P07355 (/IEP) P07355 (/IEP) P07355 (/IEP) P07355 (/IEP)
(4 more)
Membrane raft assembly GO:0001765
The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.
14 P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP)
(4 more)
Positive regulation of receptor recycling GO:0001921
Any process that activates or increases the frequency, rate or extent of receptor recycling.
14 P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(4 more)
Vesicle budding from membrane GO:0006900
The evagination of a membrane, resulting in formation of a vesicle.
14 P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP)
(4 more)
Negative regulation of low-density lipoprotein particle receptor catabolic process GO:0032804
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors.
14 P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(4 more)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
14 P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS)
(4 more)
Osteoclast development GO:0036035
The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
14 P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(4 more)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
14 P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS)
(4 more)
Positive regulation of vacuole organization GO:0044090
Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.
14 P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP)
(4 more)
Negative regulation of development of symbiont involved in interaction with host GO:0044147
Any process that stops, prevents, or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism.
14 P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP)
(4 more)
Protein heterotetramerization GO:0051290
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
14 P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(4 more)
Catabolism by host of symbiont protein GO:0052362
The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
14 P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP)
(4 more)
Negative regulation by host of symbiont molecular function GO:0052405
Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of symbiont proteins. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
14 P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP) P07355 (/IMP)
(4 more)
Positive regulation of low-density lipoprotein particle clearance GO:1905581
Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle clearance.
14 P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(4 more)
Positive regulation of low-density lipoprotein particle receptor binding GO:1905597
Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle receptor binding.
14 P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(4 more)
Positive regulation of receptor-mediated endocytosis involved in cholesterol transport GO:1905602
Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport.
14 P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(4 more)
Monocyte chemotaxis GO:0002548
The movement of a monocyte in response to an external stimulus.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
Positive regulation of interleukin-2 production GO:0032743
Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
Positive regulation of T-helper 1 cell differentiation GO:0045627
Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
Negative regulation of T-helper 2 cell differentiation GO:0045629
Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
Negative regulation of exocytosis GO:0045920
Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
Regulation of hormone secretion GO:0046883
Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
Granulocyte chemotaxis GO:0071621
The movement of a granulocyte in response to an external stimulus.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
11 P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS)
(1 more)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
11 P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS)
(1 more)
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
10 A5A6M2 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS) Q5REL2 (/ISS) Q5REL2 (/ISS) Q8HZM6 (/ISS)
Plasma membrane repair GO:0001778
The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.
8 A8KBY8 (/IMP) F1QSK0 (/IMP) F1R6N3 (/IMP) F1R6N3 (/IMP) F6IA10 (/IMP) F8W331 (/IMP) F8W331 (/IMP) Q6DG13 (/IMP)
Neutrophil homeostasis GO:0001780
The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
6 P04083 (/IMP) P04083 (/IMP) P04083 (/IMP) P04083 (/IMP) P10107 (/IMP) P10107 (/IMP)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
6 P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
6 P14668 (/IDA) P50995 (/IDA) P50995 (/IDA) P50995 (/IDA) P50995 (/IDA) Q6IRJ7 (/IDA)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
6 P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P46193 (/IDA) P79134 (/IDA)
Regulation of cell motility GO:2000145
Any process that modulates the frequency, rate or extent of cell motility.
6 A0A0R4IKN3 (/IGI) A9JTC0 (/IGI) O57570 (/IGI) Q6P0V8 (/IGI) Q803A1 (/IGI) Q804G6 (/IGI)
Biomineral tissue development GO:0031214
Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.
5 P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P79134 (/IDA)
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
5 P04272 (/IMP) P04272 (/IMP) P04272 (/IMP) P04272 (/IMP) P79134 (/IMP)
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
5 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P07150 (/IDA)
Negative regulation of interleukin-8 secretion GO:2000483
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion.
5 P04083 (/IMP) P04083 (/IMP) P04083 (/IMP) P04083 (/IMP) P09525 (/IMP)
Monocyte chemotaxis GO:0002548
The movement of a monocyte in response to an external stimulus.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
4 P50995 (/IEP) P50995 (/IEP) P50995 (/IEP) P50995 (/IEP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
4 P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P04083 (/TAS)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
4 P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P04083 (/TAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
4 P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P04083 (/TAS)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
4 P04083 (/IMP) P04083 (/IMP) P04083 (/IMP) P04083 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Peptide cross-linking GO:0018149
The formation of a covalent cross-link between or within protein chains.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P04083 (/TAS)
Keratinocyte differentiation GO:0030216
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Positive regulation of vesicle fusion GO:0031340
Any process that activates or increases the frequency, rate or extent of vesicle fusion.
4 P07356 (/ISO) P07356 (/ISO) P10107 (/ISO) P10107 (/ISO)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Cytokinetic process GO:0032506
A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).
4 P50995 (/IMP) P50995 (/IMP) P50995 (/IMP) P50995 (/IMP)
Positive regulation of interleukin-2 production GO:0032743
Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Cellular response to vascular endothelial growth factor stimulus GO:0035924
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Positive regulation of T-helper 1 cell differentiation GO:0045627
Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Negative regulation of T-helper 2 cell differentiation GO:0045629
Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Negative regulation of exocytosis GO:0045920
Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.
4 P04083 (/IMP) P04083 (/IMP) P04083 (/IMP) P04083 (/IMP)
Alpha-beta T cell differentiation GO:0046632
The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex.
4 P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS)
Regulation of hormone secretion GO:0046883
Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.
4 P04083 (/IMP) P04083 (/IMP) P04083 (/IMP) P04083 (/IMP)
Calcium ion homeostasis GO:0055074
Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.
4 P17153 (/TAS) P17785 (/TAS) P17785 (/TAS) P51901 (/TAS)
Granulocyte chemotaxis GO:0071621
The movement of a granulocyte in response to an external stimulus.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Neutrophil clearance GO:0097350
The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms.
4 P04083 (/IMP) P04083 (/IMP) P04083 (/IMP) P04083 (/IMP)
Cytokinetic process GO:0032506
A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).
3 P27214 (/ISS) P33477 (/ISS) P97384 (/ISS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
3 P10107 (/ISO) P10107 (/ISO) P48036 (/ISO)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
3 P08133 (/IMP) P08133 (/IMP) P14668 (/IMP)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
3 P48036 (/ISO) P97384 (/ISO) Q07076 (/ISO)
Negative regulation of interleukin-8 secretion GO:2000483
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion.
3 P10107 (/ISO) P10107 (/ISO) P97429 (/ISO)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 P07356 (/IMP) P07356 (/IMP)
Membrane raft assembly GO:0001765
The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.
2 P07356 (/ISO) P07356 (/ISO)
Neutrophil homeostasis GO:0001780
The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.
2 P10107 (/ISO) P10107 (/ISO)
Positive regulation of receptor recycling GO:0001921
Any process that activates or increases the frequency, rate or extent of receptor recycling.
2 P07356 (/IMP) P07356 (/IMP)
Positive regulation of receptor recycling GO:0001921
Any process that activates or increases the frequency, rate or extent of receptor recycling.
2 P07356 (/ISO) P07356 (/ISO)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
2 P07356 (/ISO) P07356 (/ISO)
Monocyte chemotaxis GO:0002548
The movement of a monocyte in response to an external stimulus.
2 P10107 (/ISO) P10107 (/ISO)
Regulation of leukocyte migration GO:0002685
Any process that modulates the frequency, rate, or extent of leukocyte migration.
2 P10107 (/IMP) P10107 (/IMP)
Growth plate cartilage development GO:0003417
The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow.
2 P17785 (/IDA) P17785 (/IDA)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
2 P24639 (/IMP) Q07076 (/IMP)
Vesicle budding from membrane GO:0006900
The evagination of a membrane, resulting in formation of a vesicle.
2 P07356 (/ISO) P07356 (/ISO)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
2 P10107 (/IMP) P10107 (/IMP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
2 P10107 (/IMP) P10107 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 P10107 (/IMP) P10107 (/IMP)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 P10107 (/ISO) P10107 (/ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187
The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
2 P10107 (/ISO) P10107 (/ISO)
Body fluid secretion GO:0007589
The controlled release of a fluid by a cell or tissue in an animal.
2 P07356 (/ISO) P07356 (/ISO)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
2 P10107 (/ISO) P10107 (/ISO)
Regulation of plasminogen activation GO:0010755
Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.
2 P17785 (/IDA) P17785 (/IDA)
Myoblast migration involved in skeletal muscle regeneration GO:0014839
The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
2 P10107 (/IDA) P10107 (/IDA)
Peptide cross-linking GO:0018149
The formation of a covalent cross-link between or within protein chains.
2 P10107 (/ISO) P10107 (/ISO)
Insulin secretion GO:0030073
The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
2 P10107 (/ISO) P10107 (/ISO)
Collagen fibril organization GO:0030199
Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.
2 P07356 (/IMP) P07356 (/IMP)
Keratinocyte differentiation GO:0030216
The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.
2 P10107 (/ISO) P10107 (/ISO)
Bone mineralization GO:0030282
The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
2 P17785 (/TAS) P17785 (/TAS)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
2 P09525 (/IEP) P20073 (/IEP)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
2 Q7T3A8 (/IEP) Q804H2 (/IEP)
Positive regulation of prostaglandin biosynthetic process GO:0031394
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.
2 P10107 (/ISO) P10107 (/ISO)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
2 P10107 (/ISO) P10107 (/ISO)
Positive regulation of chondrocyte differentiation GO:0032332
Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.
2 P17785 (/IDA) P17785 (/IDA)
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
2 P10107 (/ISO) P10107 (/ISO)
Regulation of interleukin-1 production GO:0032652
Any process that modulates the frequency, rate, or extent of interleukin-1 production.
2 P10107 (/IMP) P10107 (/IMP)
Positive regulation of interleukin-2 production GO:0032743
Any process that activates or increases the frequency, rate, or extent of interleukin-2 production.
2 P10107 (/ISO) P10107 (/ISO)
Negative regulation of low-density lipoprotein particle receptor catabolic process GO:0032804
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors.
2 P07356 (/IMP) P07356 (/IMP)
Negative regulation of low-density lipoprotein particle receptor catabolic process GO:0032804
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors.
2 P07356 (/ISO) P07356 (/ISO)
Transforming growth factor beta3 production GO:0032907
The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
2 P17785 (/IDA) P17785 (/IDA)
Positive regulation of neutrophil apoptotic process GO:0033031
Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process.
2 P10107 (/IMP) P10107 (/IMP)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
2 P08133 (/IMP) P08133 (/IMP)
Cellular response to vascular endothelial growth factor stimulus GO:0035924
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
2 P10107 (/ISO) P10107 (/ISO)
Osteoclast development GO:0036035
The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
2 P07356 (/ISO) P07356 (/ISO)
Transforming growth factor beta3 activation GO:0036366
The release of transforming growth factor beta 3 (TGF-beta3) from its latent state.
2 P17785 (/IDA) P17785 (/IDA)
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
2 P10107 (/ISO) P10107 (/ISO)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
2 P10107 (/IMP) P10107 (/IMP)
Fibrinolysis GO:0042730
A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.
2 P07356 (/IMP) P07356 (/IMP)
Positive regulation of vacuole organization GO:0044090
Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.
2 P07356 (/ISO) P07356 (/ISO)
Negative regulation of development of symbiont involved in interaction with host GO:0044147
Any process that stops, prevents, or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism.
2 P07356 (/ISO) P07356 (/ISO)
Positive regulation of T-helper 1 cell differentiation GO:0045627
Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation.
2 P10107 (/ISO) P10107 (/ISO)
Negative regulation of T-helper 2 cell differentiation GO:0045629
Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.
2 P10107 (/ISO) P10107 (/ISO)
Negative regulation of exocytosis GO:0045920
Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.
2 P10107 (/ISO) P10107 (/ISO)
Alpha-beta T cell differentiation GO:0046632
The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex.
2 P10107 (/IMP) P10107 (/IMP)
Regulation of hormone secretion GO:0046883
Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.
2 P10107 (/ISO) P10107 (/ISO)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
2 P07356 (/ISO) P07356 (/ISO)
Arachidonic acid secretion GO:0050482
The controlled release of arachidonic acid from a cell or a tissue.
2 P10107 (/IMP) P10107 (/IMP)
Negative regulation of protein secretion GO:0050709
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
2 P10107 (/ISO) P10107 (/ISO)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
2 P10107 (/IMP) P10107 (/IMP)
Positive regulation of binding GO:0051099
Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.
2 P07356 (/IMP) P07356 (/IMP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 P14824 (/ISO) P48036 (/ISO)
Negative regulation of sequestering of calcium ion GO:0051283
Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.
2 P79134 (/IDA) P81287 (/IDA)
Protein heterotetramerization GO:0051290
The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical.
2 P07356 (/ISO) P07356 (/ISO)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
2 P07150 (/IEP) P14669 (/IEP)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P17785 (/IDA) P17785 (/IDA)
Catabolism by host of symbiont protein GO:0052362
The chemical reactions and pathways performed by an organism resulting in the breakdown of protein macromolecules within the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
2 P07356 (/ISO) P07356 (/ISO)
Negative regulation by host of symbiont molecular function GO:0052405
Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the functional activity of symbiont proteins. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.
2 P07356 (/ISO) P07356 (/ISO)
Endocardial cell differentiation GO:0060956
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers.
2 P17785 (/IDA) P17785 (/IDA)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
2 P10107 (/ISO) P10107 (/ISO)
Prolactin secretion GO:0070459
The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary.
2 P10107 (/ISO) P10107 (/ISO)
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
2 P10107 (/IMP) P10107 (/IMP)
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
2 P10107 (/ISO) P10107 (/ISO)
Granulocyte chemotaxis GO:0071621
The movement of a granulocyte in response to an external stimulus.
2 P10107 (/ISO) P10107 (/ISO)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
2 P07356 (/ISO) P07356 (/ISO)
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
2 P10107 (/ISO) P10107 (/ISO)
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
2 P10107 (/ISO) P10107 (/ISO)
Response to thyroid hormone GO:0097066
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.
2 P14668 (/IEP) Q07936 (/IEP)
Neutrophil clearance GO:0097350
The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms.
2 P10107 (/ISO) P10107 (/ISO)
Positive regulation of G1/S transition of mitotic cell cycle GO:1900087
Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
2 P10107 (/IMP) P10107 (/IMP)
Negative regulation of phospholipase A2 activity GO:1900138
Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase A2 activity.
2 P07150 (/IDA) P13928 (/IDA)
Negative regulation of phospholipase A2 activity GO:1900138
Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase A2 activity.
2 P10107 (/ISO) P10107 (/ISO)
Positive regulation of low-density lipoprotein particle clearance GO:1905581
Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle clearance.
2 P07356 (/IMP) P07356 (/IMP)
Positive regulation of low-density lipoprotein particle clearance GO:1905581
Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle clearance.
2 P07356 (/ISO) P07356 (/ISO)
Positive regulation of low-density lipoprotein particle receptor binding GO:1905597
Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle receptor binding.
2 P07356 (/IMP) P07356 (/IMP)
Positive regulation of low-density lipoprotein particle receptor binding GO:1905597
Any process that activates or increases the frequency, rate or extent of low-density lipoprotein particle receptor binding.
2 P07356 (/ISO) P07356 (/ISO)
Positive regulation of low-density lipoprotein receptor activity GO:1905599
Any process that activates or increases the frequency, rate or extent of low-density lipoprotein receptor activity.
2 P07356 (/ISO) P07356 (/ISO)
Positive regulation of receptor-mediated endocytosis involved in cholesterol transport GO:1905602
Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport.
2 P07356 (/IMP) P07356 (/IMP)
Positive regulation of receptor-mediated endocytosis involved in cholesterol transport GO:1905602
Any process that activates or increases the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport.
2 P07356 (/ISO) P07356 (/ISO)
Neural crest cell migration GO:0001755
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
1 P51901 (/IMP)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
1 P97429 (/ISA)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 Q07936 (/IMP)
Growth plate cartilage chondrocyte differentiation GO:0003418
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage.
1 P79134 (/IDA)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P09525 (/IDA)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P97429 (/ISO)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P14824 (/IMP)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P79134 (/ISS)
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
1 P55260 (/NAS)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 P12429 (/IDA)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 O35639 (/ISO)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
1 P20073 (/IMP)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
1 Q07076 (/ISO)
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
1 P14824 (/IMP)
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
1 P79134 (/ISS)
Plasma membrane organization GO:0007009
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
1 P24639 (/IMP)
Endosome organization GO:0007032
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
1 P13928 (/IMP)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P07150 (/IDA)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P97429 (/IDA)
Body fluid secretion GO:0007589
The controlled release of a fluid by a cell or tissue in an animal.
1 Q07936 (/IMP)
Hemostasis GO:0007599
The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.
1 Q07076 (/IMP)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q07076 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
1 Q07076 (/IMP)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 P24639 (/HEP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
1 Q07076 (/IMP)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 P07150 (/IEP)
Cellular water homeostasis GO:0009992
Any process involved in the maintenance of an internal steady state of water within a cell.
1 Q07076 (/IMP)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 P48036 (/IDA)
Response to X-ray GO:0010165
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).
1 P07150 (/IEP)
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 P12429 (/IDA)
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 O35639 (/ISO)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P20073 (/IMP)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q07076 (/ISO)
Regulation of multivesicular body size involved in endosome transport GO:0010797
Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles.
1 P22464 (/IMP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 Q6IRJ7 (/IDA)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 P07150 (/IEP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 Q07076 (/ISO)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
1 P13928 (/IMP)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
1 P14669 (/IEP)
Maintenance of cell polarity GO:0030011
The maintenance of established anisotropic intracellular organization or cell growth patterns.
1 P22464 (/IMP)
Insulin secretion GO:0030073
The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects.
1 P07150 (/IDA)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
1 P27216 (/NAS)
Negative regulation of blood coagulation GO:0030195
Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.
1 P14668 (/IDA)
Negative regulation of blood coagulation GO:0030195
Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.
1 P48036 (/ISO)
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
1 P24639 (/IMP)
Prostate gland development GO:0030850
The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.
1 P07150 (/IEP)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
1 P07150 (/IEP)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
1 P14669 (/IEP)
Positive regulation of prostaglandin biosynthetic process GO:0031394
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.
1 P07150 (/IMP)
Response to corticosteroid GO:0031960
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids.
1 P07150 (/IEP)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 P09525 (/IDA)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 P97429 (/ISO)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P07150 (/IEP)
Cytokinetic process GO:0032506
A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).
1 P97384 (/ISO)
DNA duplex unwinding GO:0032508
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.
1 P07150 (/IDA)
Endosome transport via multivesicular body sorting pathway GO:0032509
The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.
1 P22464 (/IMP)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
1 P14824 (/ISO)
Gliogenesis GO:0042063
The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.
1 P07150 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P07150 (/IEP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 P12429 (/IDA)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 O35639 (/ISO)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 P14668 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 P07150 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 P12429 (/IDA)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 O35639 (/ISO)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 P07150 (/IEP)
Engulfment of apoptotic cell GO:0043652
The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.
1 G5EEA8 (/IMP)
Positive regulation by host of viral process GO:0044794
A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected.
1 P19620 (/IMP)
Estrous cycle GO:0044849
A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur.
1 P07150 (/IEP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 P12429 (/IDA)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 O35639 (/ISO)
Secretion GO:0046903
The controlled release of a substance by a cell or a tissue.
1 P48037 (/TAS)
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
1 Q07936 (/IMP)
Wing disc dorsal/ventral pattern formation GO:0048190
The establishment, maintenance and elaboration of the dorsal/ventral axis of the wing disc, a precursor to the adult wing.
1 P22464 (/IGI)
Negative regulation of protein secretion GO:0050709
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.
1 P07150 (/IMP)
Positive regulation of DNA metabolic process GO:0051054
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.
1 P14669 (/IMP)
Positive regulation of DNA metabolic process GO:0051054
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.
1 O35639 (/ISO)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 P12429 (/IDA)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 O35639 (/ISO)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P14668 (/IDA)
Mitochondrial calcium ion homeostasis GO:0051560
Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
1 P14824 (/IMP)
Regulation of fibrinolysis GO:0051917
Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.
1 Q07936 (/TAS)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 Q6IRJ7 (/IDA)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 Q07076 (/ISO)
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 P07150 (/IMP)
Hepatocyte differentiation GO:0070365
The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.
1 P07150 (/IEP)
Prolactin secretion GO:0070459
The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary.
1 P07150 (/IMP)
Response to interleukin-1 GO:0070555
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 P07150 (/IEP)
Response to growth factor GO:0070848
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
1 P14669 (/IEP)
Cellular response to lead ion GO:0071284
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
1 P14668 (/IEP)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
1 Q07936 (/IMP)
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
1 P14824 (/IMP)
Cellular response to gonadotropin-releasing hormone GO:0097211
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.
1 P14668 (/IMP)
Cellular response to gonadotropin-releasing hormone GO:0097211
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.
1 P48036 (/ISO)
Negative regulation of serine-type endopeptidase activity GO:1900004
Any process that stops, prevents or reduces the frequency, rate or extent of serine-type endopeptidase activity.
1 P13928 (/IDA)
Regulation of flagellated sperm motility GO:1901317
Any process that modulates the frequency, rate or extent of flagellated sperm motility.
1 P14668 (/IDA)
Regulation of flagellated sperm motility GO:1901317
Any process that modulates the frequency, rate or extent of flagellated sperm motility.
1 P48036 (/ISO)
Negative regulation of prolactin secretion GO:1902721
Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion.
1 P14668 (/IMP)
Negative regulation of prolactin secretion GO:1902721
Any process that stops, prevents or reduces the frequency, rate or extent of prolactin secretion.
1 P48036 (/ISO)
Positive regulation of viral life cycle GO:1903902
Any process that activates or increases the frequency, rate or extent of viral life cycle.
1 P19620 (/IMP)

There are 163 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
43 O35639 (/HDA) P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA)
(33 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
41 A0A0R4IKN3 (/IDA) A9JTC0 (/IDA) O57570 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P07150 (/IDA) P07355 (/IDA) P07355 (/IDA)
(31 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
35 G5EEA8 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P07150 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(25 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
35 A6NMY6 (/HDA) P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA)
(25 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
32 D6RA82 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P07356 (/IDA)
(22 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
28 A2SW69 (/ISS) A2SW69 (/ISS) A2SW69 (/ISS) A2SW69 (/ISS) A5A6M2 (/ISS) P14087 (/ISS) P14087 (/ISS) P19620 (/ISS) P24551 (/ISS) P51662 (/ISS)
(18 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
27 P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA)
(17 more)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
26 A2SW69 (/ISS) A2SW69 (/ISS) A2SW69 (/ISS) A2SW69 (/ISS) P04272 (/ISS) P04272 (/ISS) P04272 (/ISS) P04272 (/ISS) P19620 (/ISS) Q2Q1M6 (/ISS)
(16 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
24 P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS)
(14 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
21 P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA)
(11 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
21 B5XAE0 (/IDA) B5XEI6 (/IDA) C0H815 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(11 more)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
19 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(9 more)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
18 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(8 more)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
18 P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA)
(8 more)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
18 P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(8 more)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
18 P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA)
(8 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
17 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P07150 (/IDA) P09525 (/IDA)
(7 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
17 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P27216 (/IDA) P50995 (/IDA) P50995 (/IDA) P50995 (/IDA) P50995 (/IDA) Q5T0G8 (/IDA)
(7 more)
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
17 P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(7 more)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
16 P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(6 more)
Extrinsic component of endosome membrane GO:0031313
The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
16 A5A6M2 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS)
(6 more)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
16 A5A6M2 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS)
(6 more)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
15 A5A6M2 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P07150 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS)
(5 more)
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
15 A5A6M2 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P07150 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS)
(5 more)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
15 A5A6M2 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P04083 (/ISS) P07150 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS)
(5 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
14 P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA)
(4 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
14 P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA) P07355 (/HDA)
(4 more)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
14 P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(4 more)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
14 P07355 (/ISS) P07355 (/ISS) P07355 (/ISS) P07355 (/ISS) P07355 (/ISS) P07355 (/ISS) P07355 (/ISS) P07355 (/ISS) P07355 (/ISS) P07355 (/ISS)
(4 more)
Azurophil granule lumen GO:0035578
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
14 P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS) P07355 (/TAS)
(4 more)
PCSK9-AnxA2 complex GO:1990667
A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and Annexin A2 (AnxA2).
14 P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA) P07355 (/IDA)
(4 more)
Extrinsic component of external side of plasma membrane GO:0031232
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
13 A5A6M2 (/ISS) P07150 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS)
(3 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
12 A5A6M2 (/ISS) P10107 (/ISS) P10107 (/ISS) P14087 (/ISS) P14087 (/ISS) P19619 (/ISS) P24551 (/ISS) P46193 (/ISS) P51662 (/ISS) Q5REL2 (/ISS)
(2 more)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
12 P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P04083 (/HDA) P08133 (/HDA) P08133 (/HDA) P08758 (/HDA) P08758 (/HDA) P08758 (/HDA) P08758 (/HDA)
(2 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
11 P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P04083 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS)
(1 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 P07356 (/TAS) P07356 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P08758 (/TAS) P10107 (/TAS) P10107 (/TAS)
(1 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
11 P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P12429 (/IDA) P13214 (/IDA) P46193 (/IDA) P48037 (/IDA) P79134 (/IDA) P81287 (/IDA)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 O35639 (/ISO) P07356 (/ISO) P07356 (/ISO) P10107 (/ISO) P10107 (/ISO) P14824 (/ISO) P48036 (/ISO) P97384 (/ISO) P97429 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 O35639 (/ISO) O35640 (/ISO) P07356 (/ISO) P07356 (/ISO) P10107 (/ISO) P10107 (/ISO) P48036 (/ISO) P97429 (/ISO) Q99JG3 (/ISO)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
9 P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P17785 (/IDA) P17785 (/IDA) P79134 (/IDA) Q07076 (/IDA) Q07936 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 O35639 (/ISO) O35640 (/ISO) P07356 (/ISO) P07356 (/ISO) P10107 (/ISO) P10107 (/ISO) P48036 (/ISO) P97384 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
6 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P07150 (/IDA) P14668 (/IDA)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
6 P08758 (/IDA) P08758 (/IDA) P08758 (/IDA) P08758 (/IDA) P08758 (/IDA) P08758 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
6 P10107 (/ISO) P10107 (/ISO) P14824 (/ISO) P48036 (/ISO) P97429 (/ISO) Q07076 (/ISO)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
6 P07356 (/IDA) P07356 (/IDA) P10107 (/IDA) P10107 (/IDA) P14668 (/IDA) P48037 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
5 P50995 (/IDA) P50995 (/IDA) P50995 (/IDA) P50995 (/IDA) Q07076 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
5 P07356 (/ISO) P07356 (/ISO) P10107 (/ISO) P10107 (/ISO) P97429 (/ISO)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
5 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P27216 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
5 P07150 (/IDA) P17785 (/IDA) P17785 (/IDA) P48037 (/IDA) Q07936 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
5 P07356 (/ISO) P07356 (/ISO) P10107 (/ISO) P10107 (/ISO) P14824 (/ISO)
Specific granule GO:0042581
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
5 P12429 (/IDA) P50995 (/IDA) P50995 (/IDA) P50995 (/IDA) P50995 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
5 G5EEA8 (/IDA) P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P04272 (/IDA)
Cornified envelope GO:0001533
A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes).
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
4 P50995 (/NAS) P50995 (/NAS) P50995 (/NAS) P50995 (/NAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 P10107 (/ISO) P10107 (/ISO) P97384 (/ISO) Q99JG3 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 P50995 (/NAS) P50995 (/NAS) P50995 (/NAS) P50995 (/NAS)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
4 P07356 (/ISO) P07356 (/ISO) P10107 (/ISO) P10107 (/ISO)
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
4 P50995 (/IDA) P50995 (/IDA) P50995 (/IDA) P50995 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P04272 (/TAS) P04272 (/TAS) P04272 (/TAS) P04272 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 O35639 (/ISO) P07356 (/ISO) P07356 (/ISO) P14824 (/ISO)
Extrinsic component of external side of plasma membrane GO:0031232
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.
4 P04083 (/IDA) P04083 (/IDA) P04083 (/IDA) P04083 (/IDA)
Late endosome membrane GO:0031902
The lipid bilayer surrounding a late endosome.
4 O35640 (/ISO) P07356 (/ISO) P07356 (/ISO) P14824 (/ISO)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
4 P17153 (/TAS) P17785 (/TAS) P17785 (/TAS) P51901 (/TAS)
Calcium channel complex GO:0034704
An ion channel complex through which calcium ions pass.
4 P17153 (/TAS) P17785 (/TAS) P17785 (/TAS) P51901 (/TAS)
Azurophil granule GO:0042582
Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
4 P50995 (/IDA) P50995 (/IDA) P50995 (/IDA) P50995 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
4 P50995 (/IDA) P50995 (/IDA) P50995 (/IDA) P50995 (/IDA)
Extracellular membrane-bounded organelle GO:0065010
Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.
4 P04272 (/IDA) P04272 (/IDA) P04272 (/IDA) P04272 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 P07356 (/ISO) P07356 (/ISO) P10107 (/ISO) P10107 (/ISO)
Exocytic vesicle GO:0070382
A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
4 F1P6B7 (/IDA) Q29471 (/IDA) Q6TEQ7 (/IDA) Q6TEQ7 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 P10107 (/ISO) P10107 (/ISO) P48036 (/ISO)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
3 P07356 (/ISO) P07356 (/ISO) P14824 (/ISO)
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
3 P27214 (/ISS) P33477 (/ISS) P97384 (/ISS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
3 P10107 (/IDA) P10107 (/IDA) P48037 (/IDA)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
3 P07356 (/ISO) P07356 (/ISO) P97384 (/ISO)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
3 P27214 (/ISS) P33477 (/ISS) P97384 (/ISS)
Chromaffin granule membrane GO:0042584
The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.
3 P13214 (/IDA) P20072 (/IDA) P79134 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
3 P09525 (/IDA) P14824 (/IDA) Q07936 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
3 P07356 (/ISO) P07356 (/ISO) P97429 (/ISO)
Cornified envelope GO:0001533
A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes).
2 P10107 (/ISO) P10107 (/ISO)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
2 P07356 (/ISO) P07356 (/ISO)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
2 P07356 (/IDA) P07356 (/IDA)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
2 P07356 (/ISO) P07356 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P10107 (/IMP) P10107 (/IMP)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
2 P22464 (/IDA) Q07936 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
2 P07356 (/ISO) P07356 (/ISO)
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
2 P14668 (/IDA) P48037 (/IDA)
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
2 P14824 (/ISO) P48036 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P79134 (/IDA) P81287 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 P07356 (/IDA) P07356 (/IDA)
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
2 P10107 (/IDA) P10107 (/IDA)
Extrinsic component of plasma membrane GO:0019897
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
2 P07356 (/IDA) P07356 (/IDA)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
2 P10107 (/ISO) P10107 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 P14668 (/IDA) P14669 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 O35639 (/ISO) P48036 (/ISO)
Extrinsic component of external side of plasma membrane GO:0031232
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.
2 P10107 (/ISO) P10107 (/ISO)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
2 P10107 (/IDA) P10107 (/IDA)
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
2 P10107 (/ISO) P10107 (/ISO)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
2 P07356 (/ISO) P07356 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 P17785 (/TAS) P17785 (/TAS)
Myelin sheath adaxonal region GO:0035749
The region of the myelin sheath nearest to the axon.
2 P07356 (/IDA) P07356 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
2 P14824 (/ISO) P48036 (/ISO)
Specific granule GO:0042581
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
2 O35639 (/ISO) P97384 (/ISO)
Mast cell granule GO:0042629
Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase.
2 P10107 (/ISO) P10107 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 P14668 (/IDA) P14669 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 O35639 (/ISO) P48036 (/ISO)
Schmidt-Lanterman incisure GO:0043220
Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier.
2 P07356 (/IDA) P07356 (/IDA)
Macropinosome GO:0044354
A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.
2 P07356 (/ISO) P07356 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
2 P07356 (/ISO) P07356 (/ISO)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
2 P17785 (/IDA) P17785 (/IDA)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
2 P10107 (/ISO) P10107 (/ISO)
PCSK9-AnxA2 complex GO:1990667
A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and Annexin A2 (AnxA2).
2 P07356 (/ISO) P07356 (/ISO)
PCSK9-AnxA2 complex GO:1990667
A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and Annexin A2 (AnxA2).
2 P07356 (/ISS) P07356 (/ISS)
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
1 P79134 (/IMP)
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
1 Q07936 (/IDA)
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
1 P81287 (/ISS)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 P97384 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 P14668 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 P48036 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 P20073 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q07076 (/ISO)
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
1 P97384 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P27216 (/NAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 P79134 (/IMP)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
1 P14668 (/IDA)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
1 P48036 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 P48036 (/IDA)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 P24639 (/IDA)
Endomembrane system GO:0012505
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
1 P22464 (/IDA)
Vesicle membrane GO:0012506
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
1 P09525 (/IDA)
Vesicle membrane GO:0012506
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
1 P97429 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P22465 (/IC)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P79134 (/TAS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 P97429 (/ISA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 P14824 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 P13214 (/TAS)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 P14668 (/IDA)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 P48036 (/ISO)
Mitochondrial crista GO:0030061
Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.
1 P79134 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 P14669 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 O35639 (/ISO)
Phagocytic vesicle membrane GO:0030670
The lipid bilayer surrounding a phagocytic vesicle.
1 P12429 (/IDA)
Phagocytic vesicle membrane GO:0030670
The lipid bilayer surrounding a phagocytic vesicle.
1 O35639 (/ISO)
Extrinsic component of endosome membrane GO:0031313
The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 P19619 (/IDA)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
1 P19619 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 P09525 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 P97429 (/ISO)
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
1 P07150 (/IDA)
Azurophil granule GO:0042582
Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.
1 P97384 (/ISO)
Mast cell granule GO:0042629
Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase.
1 P07150 (/IDA)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
1 P14668 (/IDA)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
1 P48036 (/ISO)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 P14668 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 P48036 (/ISO)
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
1 P14668 (/IDA)
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
1 P48036 (/ISO)
Macropinosome GO:0044354
A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.
1 Q07936 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 Q07936 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 P24639 (/HDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 P97384 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P79134 (/ISS)
Endothelial microparticle GO:0072563
A blood microparticle that is derived from, and contains membrane receptors as well as other proteins characteristic of, an endothelial cell.
1 P48036 (/IDA)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
1 P07150 (/IDA)