The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Retrovirus capsid C-terminal domain

The Gag polyprotein from retroviruses is processed by viral protease to produce the major structural proteins, including the capsid protein. The newly formed capsid protein rearranges to form the capsid core particle that surrounds the viral genome of the mature virus. The capsid is composed of two domains, the N-terminal domain (NTD), which contributes to viral core formation, and the C-terminal domain (CTD), which is required for capsid dimerisation, Gag oligomerization and viral formation. The CTD contains the major homology region (MHR), a stretch of 20 amino acids that is conserved across retroviruses and is essential for viral assembly, maturation and infectivity. This entry represents the CTD which is composed of a bundle of four helices in an up and down arrangement, where helix 3 is shorter than the others.

PMID:9346481 PMID:9931251 PMID:10669613

GO Diversity

Unique GO annotations
25 Unique GO terms

EC Diversity

Unique EC annotations
9 Unique EC terms

Species Diversity

Unique species annotations
214 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 185
Domain clusters (>95% seq id): 16
Domain clusters (>35% seq id): 8
Unique PDBs: 80
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 5
Unique EC: 9
Unique GO: 25
Unique Species: 214