CATH Superfamily 1.10.10.1000
Type III secretion system virulence factor YopR, core domain
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"The YopR core domain, predominantly found in the Gammaproteobacteria virulence factor YopR, is composed of five alpha-helices, four of which are arranged in an antiparallel bundle. Little is known about this domain, though it may contribute to the virulence of the protein YopR PMID:15930010. YopR controls the selective access of early (YscF, YscI and YscP) substrates to the type III secretion machines of yersiniae and other Gammaproteobacteriae. YopR is a mobile regulatory component thought to function as a checkpoints probing the completion of discrete intermediary stages in the assembly of the type III injection pathway. The location of secreted YopR (into the medium) is directly controlling the secretion of YscF, the polymerised needle protein (PFAM:PF09392) thereby impacting the assembly of type III machines PMID:19968786.
Structures | |
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Domains: | 1 |
Domain clusters (>95% seq id): | 1 |
Domain clusters (>35% seq id): | 1 |
Unique PDBs: | 1 |
Alignments | |
Structural Clusters (5A): | 1 |
Structural Clusters (9A): | 1 |
FunFam Clusters: | 1 |
Function | |
Unique EC: | |
Unique GO: | 2 |
Taxonomy | |
Unique Species: | 63 |