The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 64: Lysine-specific histone demethylase 1A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 56 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 A0A0G2K736 (/IPI) A8K2R3 (/IPI) B3STT9 (/IPI) F1MA31 (/IPI) O60341 (/IPI) Q6ZQ88 (/IPI) Q9LID0 (/IPI) Q9VW97 (/IPI) Q9VW97 (/IPI) Q9XWP6 (/IPI)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
4 A0A0G2K736 (/IDA) B3STT9 (/IDA) F1MA31 (/IDA) O60341 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
4 A0A0G2K736 (/IPI) B3STT9 (/IPI) F1MA31 (/IPI) Q6ZQ88 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
2 Q10135 (/ISM) Q9Y802 (/ISM)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 O60341 (/IPI) Q6ZQ88 (/IPI)
Histone demethylase activity (H3-K4 specific) GO:0032453
Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.
2 Q9VW97 (/IMP) Q9VW97 (/IMP)
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
2 O60341 (/IDA) Q9Y802 (/IDA)
Histone demethylase activity (H3-dimethyl-K4 specific) GO:0034648
Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein.
2 O60341 (/IDA) Q6ZQ88 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q6ZQ88 (/IDA)
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
1 Q6ZQ88 (/IPI)
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
1 O60341 (/ISS)
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
1 O60341 (/IPI)
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
1 Q6ZQ88 (/ISO)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q6ZQ88 (/ISO)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q6ZQ88 (/ISS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q6ZQ88 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 O60341 (/IDA)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 Q6ZQ88 (/ISO)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
1 O60341 (/IDA)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
1 Q6ZQ88 (/ISO)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
1 Q6ZQ88 (/ISS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q6ZQ88 (/ISO)
Nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
1 O60341 (/IMP)
Nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
1 Q6ZQ88 (/ISO)
Nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
1 Q6ZQ88 (/ISS)
Demethylase activity GO:0032451
Catalysis of the removal of a methyl group from a substrate.
1 O60341 (/IMP)
Demethylase activity GO:0032451
Catalysis of the removal of a methyl group from a substrate.
1 Q6ZQ88 (/ISO)
Histone demethylase activity GO:0032452
Catalysis of the removal of a methyl group from a histone.
1 O60341 (/EXP)
Histone demethylase activity GO:0032452
Catalysis of the removal of a methyl group from a histone.
1 O60341 (/IDA)
Histone demethylase activity GO:0032452
Catalysis of the removal of a methyl group from a histone.
1 Q6ZQ88 (/ISO)
Histone demethylase activity GO:0032452
Catalysis of the removal of a methyl group from a histone.
1 Q6ZQ88 (/ISS)
Histone demethylase activity (H3-K4 specific) GO:0032453
Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.
1 O60341 (/IDA)
Histone demethylase activity (H3-K4 specific) GO:0032453
Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.
1 Q6ZQ88 (/ISO)
Histone demethylase activity (H3-K4 specific) GO:0032453
Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.
1 Q6ZQ88 (/ISS)
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
1 Q6ZQ88 (/ISO)
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
1 Q6ZQ88 (/ISS)
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
1 O60341 (/TAS)
Histone demethylase activity (H3-dimethyl-K4 specific) GO:0034648
Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein.
1 Q9XWP6 (/IGI)
Histone demethylase activity (H3-dimethyl-K4 specific) GO:0034648
Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein.
1 Q9XWP6 (/IMP)
Histone demethylase activity (H3-dimethyl-K4 specific) GO:0034648
Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein.
1 Q6ZQ88 (/ISO)
Histone demethylase activity (H3-dimethyl-K4 specific) GO:0034648
Catalysis of the removal of a methyl group from dimethylated lysine at position 4 of the histone H3 protein.
1 Q6ZQ88 (/ISS)
Telomeric DNA binding GO:0042162
Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.
1 O60341 (/IMP)
Telomeric DNA binding GO:0042162
Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.
1 Q6ZQ88 (/ISO)
MRF binding GO:0043426
Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors.
1 O60341 (/IDA)
MRF binding GO:0043426
Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors.
1 Q6ZQ88 (/IPI)
MRF binding GO:0043426
Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors.
1 Q6ZQ88 (/ISO)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 Q6ZQ88 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 O60341 (/ISS)
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
1 O60341 (/IDA)
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
1 Q6ZQ88 (/ISO)
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
1 Q6ZQ88 (/ISS)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
1 O60341 (/IDA)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
1 Q6ZQ88 (/ISO)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
1 Q6ZQ88 (/ISS)
Telomeric repeat-containing RNA binding GO:0061752
Interacting selectively and non-covalently with long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats.
1 O60341 (/IDA)
Telomeric repeat-containing RNA binding GO:0061752
Interacting selectively and non-covalently with long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats.
1 Q6ZQ88 (/ISO)

There are 111 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
7 A0A0G2K736 (/IMP) B3STT9 (/IMP) F1MA31 (/IMP) Q6ZQ88 (/IMP) Q9VW97 (/IMP) Q9VW97 (/IMP) Q9XWP6 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
6 A0A0P0UQI8 (/IMP) A0A2R8Q8P2 (/IMP) A0JMQ3 (/IMP) F6NIA2 (/IMP) F8W3Z9 (/IMP) F8W5U1 (/IMP)
Regulation of retinoic acid biosynthetic process GO:1900052
Any process that modulates the frequency, rate or extent of retinoic acid biosynthetic process.
6 A0A0P0UQI8 (/IGI) A0A2R8Q8P2 (/IGI) A0JMQ3 (/IGI) F6NIA2 (/IGI) F8W3Z9 (/IGI) F8W5U1 (/IGI)
Regulation of hemopoiesis GO:1903706
Any process that modulates the frequency, rate or extent of hemopoiesis.
6 A0A0P0UQI8 (/IMP) A0A2R8Q8P2 (/IMP) A0JMQ3 (/IMP) F6NIA2 (/IMP) F8W3Z9 (/IMP) F8W5U1 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 A0A0G2K736 (/IMP) B3STT9 (/IMP) F1MA31 (/IMP) Q6ZQ88 (/IMP)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
4 A0A0G2K736 (/ISS) B3STT9 (/ISS) F1MA31 (/ISS) O60341 (/ISS)
Alternative mRNA splicing, via spliceosome GO:0000380
The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.
3 A0A0G2K736 (/IEP) B3STT9 (/IEP) F1MA31 (/IEP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
3 A0A0G2K736 (/IMP) B3STT9 (/IMP) F1MA31 (/IMP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
3 A0A0G2K736 (/IEP) B3STT9 (/IEP) F1MA31 (/IEP)
Cerebral cortex development GO:0021987
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
3 A0A0G2K736 (/IEP) B3STT9 (/IEP) F1MA31 (/IEP)
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
3 O60341 (/IDA) Q10135 (/IDA) Q9Y802 (/IDA)
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
3 Q10135 (/IMP) Q6ZQ88 (/IMP) Q9Y802 (/IMP)
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
3 A0A0G2K736 (/IEP) B3STT9 (/IEP) F1MA31 (/IEP)
Positive regulation of chromatin binding GO:0035563
Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
3 A0A0G2K736 (/IMP) B3STT9 (/IMP) F1MA31 (/IMP)
Neuron maturation GO:0042551
A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.
3 A0A0G2K736 (/IEP) B3STT9 (/IEP) F1MA31 (/IEP)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
3 A0A0G2K736 (/IMP) B3STT9 (/IMP) F1MA31 (/IMP)
Guanine metabolic process GO:0046098
The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.
3 A0A0G2K736 (/IMP) B3STT9 (/IMP) F1MA31 (/IMP)
Response to fungicide GO:0060992
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi.
3 A0A0G2K736 (/IEP) B3STT9 (/IEP) F1MA31 (/IEP)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
3 A0A0G2K736 (/IEP) B3STT9 (/IEP) F1MA31 (/IEP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 O60341 (/IMP) Q6ZQ88 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
2 Q9VW97 (/IMP) Q9VW97 (/IMP)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
2 Q10135 (/ISS) Q9Y802 (/ISS)
Imaginal disc-derived wing vein specification GO:0007474
The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified.
2 Q9VW97 (/IMP) Q9VW97 (/IMP)
Gene silencing GO:0016458
Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression.
2 Q9VW97 (/IMP) Q9VW97 (/IMP)
Histone deacetylation GO:0016575
The modification of histones by removal of acetyl groups.
2 Q8VXV7 (/IMP) Q9CAE3 (/IMP)
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
2 O60341 (/IDA) Q6ZQ88 (/IDA)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
2 Q9VW97 (/IMP) Q9VW97 (/IMP)
Histone H3-K4 methylation GO:0051568
The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone.
2 Q8VXV7 (/IMP) Q9LID0 (/IMP)
Heterochromatin organization GO:0070828
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin.
2 Q9VW97 (/IMP) Q9VW97 (/IMP)
Positive regulation of methylation-dependent chromatin silencing GO:0090309
Any process that increases the rate, frequency, or extent of the repression of transcription by methylation of DNA, leading to the formation of heterochromatin.
2 Q9VW97 (/IMP) Q9VW97 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q6ZQ88 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q6ZQ88 (/ISO)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O60341 (/ISS)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 Q6ZQ88 (/IMP)
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
1 O60341 (/IMP)
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
1 Q6ZQ88 (/ISO)
Chromatin silencing GO:0006342
Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin.
1 Q6ZQ88 (/IDA)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O60341 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q6ZQ88 (/ISO)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q6ZQ88 (/ISS)
Protein demethylation GO:0006482
The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
1 O60341 (/IMP)
Protein demethylation GO:0006482
The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
1 Q6ZQ88 (/ISO)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 O60341 (/TAS)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q6ZQ88 (/IMP)
Vegetative to reproductive phase transition of meristem GO:0010228
The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence.
1 Q9CAE3 (/IMP)
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
1 O60341 (/IMP)
Regulation of double-strand break repair via homologous recombination GO:0010569
Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
1 Q6ZQ88 (/ISO)
Regulation of primitive erythrocyte differentiation GO:0010725
Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis.
1 Q6ZQ88 (/IMP)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q6ZQ88 (/ISO)
Replication fork arrest at mating type locus GO:0011000
A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus.
1 Q9Y802 (/IMP)
Pituitary gland development GO:0021983
The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.
1 Q6ZQ88 (/IMP)
Granulocyte differentiation GO:0030851
The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.
1 Q6ZQ88 (/IMP)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
1 O60341 (/IMP)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
1 Q6ZQ88 (/ISO)
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
1 Q6ZQ88 (/ISO)
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
1 Q6ZQ88 (/ISS)
Positive regulation of histone ubiquitination GO:0033184
Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin group to a histone protein.
1 O60341 (/IMP)
Positive regulation of histone ubiquitination GO:0033184
Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin group to a histone protein.
1 Q6ZQ88 (/ISO)
Cellular response to UV GO:0034644
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
1 O60341 (/IDA)
Cellular response to UV GO:0034644
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
1 Q6ZQ88 (/ISO)
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
1 Q9XWP6 (/IGI)
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
1 Q6ZQ88 (/ISO)
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
1 Q6ZQ88 (/ISS)
Positive regulation of chromatin binding GO:0035563
Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q6ZQ88 (/ISO)
Regulation of gene expression, epigenetic GO:0040029
Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.
1 Q9XWP6 (/IMP)
Negative regulation of DNA binding GO:0043392
Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).
1 O60341 (/IC)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 O60341 (/IDA)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 O60341 (/IMP)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q6ZQ88 (/ISO)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q6ZQ88 (/ISS)
Negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518
Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
1 O60341 (/IMP)
Negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518
Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
1 Q6ZQ88 (/ISO)
Positive regulation of erythrocyte differentiation GO:0045648
Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
1 Q6ZQ88 (/IMP)
Positive regulation of megakaryocyte differentiation GO:0045654
Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.
1 Q6ZQ88 (/IMP)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
1 Q6ZQ88 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 O60341 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q6ZQ88 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q6ZQ88 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 O60341 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q6ZQ88 (/ISO)
Guanine metabolic process GO:0046098
The chemical reactions and pathways involving guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important.
1 Q6ZQ88 (/ISO)
Positive regulation of hormone biosynthetic process GO:0046886
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.
1 Q6ZQ88 (/IMP)
Root development GO:0048364
The process whose specific outcome is the progression of the root over time, from its formation to the mature structure. The root is the water- and mineral-absorbing part of a plant which is usually underground, does not bear leaves, tends to grow downwards and is typically derived from the radicle of the embryo.
1 Q8VXV7 (/IMP)
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
1 Q6ZQ88 (/IGI)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
1 Q6ZQ88 (/IDA)
Negative regulation of neurogenesis GO:0050768
Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
1 Q6ZQ88 (/IMP)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 O60341 (/IDA)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q6ZQ88 (/ISO)
Regulation of meiotic cell cycle GO:0051445
Any process that modulates the rate or extent of progression through the meiotic cell cycle.
1 Q10135 (/IMP)
Negative regulation of histone H3-K4 methylation GO:0051572
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.
1 Q6ZQ88 (/IMP)
Negative regulation of histone H3-K4 methylation GO:0051572
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3.
1 O60341 (/ISS)
Negative regulation of histone H3-K9 methylation GO:0051573
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.
1 Q6ZQ88 (/IMP)
Negative regulation of histone H3-K9 methylation GO:0051573
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.
1 O60341 (/ISS)
Muscle cell development GO:0055001
The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
1 Q6ZQ88 (/IMP)
Muscle cell development GO:0055001
The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.
1 O60341 (/ISS)
Regulation of antisense RNA transcription GO:0060194
Any process that modulates the frequency, rate or extent of the synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA.
1 Q9Y802 (/IMP)
Cellular response to gamma radiation GO:0071480
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
1 O60341 (/IMP)
Cellular response to gamma radiation GO:0071480
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
1 Q6ZQ88 (/ISO)
Genetic imprinting at mating-type locus GO:0071515
A genetic imprinting process in which a stable single-strand DNA lesion triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication.
1 Q9Y802 (/IMP)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
1 Q6ZQ88 (/IMP)
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.
1 O60341 (/IMP)
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.
1 Q6ZQ88 (/ISO)
Regulation of replication fork arrest at rDNA repeats GO:1902681
Any process that modulates the frequency, rate or extent of replication fork arrest at rDNA repeats.
1 Q9Y802 (/IMP)
Regulation of cellular protein localization GO:1903827
Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
1 O60341 (/IMP)
Regulation of cellular protein localization GO:1903827
Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
1 Q6ZQ88 (/ISO)
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q6ZQ88 (/IGI)
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q6ZQ88 (/IMP)
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
1 Q6ZQ88 (/IMP)
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
1 O60341 (/ISS)
Positive regulation of stem cell proliferation GO:2000648
Any process that activates or increases the frequency, rate or extent of stem cell proliferation.
1 Q6ZQ88 (/IMP)
Positive regulation of stem cell proliferation GO:2000648
Any process that activates or increases the frequency, rate or extent of stem cell proliferation.
1 O60341 (/ISS)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 A0A0G2K736 (/IDA) B3STT9 (/IDA) F1MA31 (/IDA) O60341 (/IDA) Q6ZQ88 (/IDA) Q8VXV7 (/IDA) Q9VW97 (/IDA) Q9VW97 (/IDA) Q9XWP6 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
7 A0A0G2K736 (/IDA) B3STT9 (/IDA) F1MA31 (/IDA) O60341 (/IDA) Q10135 (/IDA) Q6ZQ88 (/IDA) Q9Y802 (/IDA)
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
2 Q9VW97 (/IPI) Q9VW97 (/IPI)
Lsd1/2 complex GO:0033193
A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast.
2 Q10135 (/IDA) Q9Y802 (/IDA)
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
1 O60341 (/IDA)
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
1 Q6ZQ88 (/ISO)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q6ZQ88 (/ISO)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 O60341 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q10135 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6ZQ88 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6ZQ88 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O60341 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q6ZQ88 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O60341 (/TAS)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 Q6ZQ88 (/IDA)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 O60341 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9XWP6 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q10135 (/HDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 O60341 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q6ZQ88 (/ISO)
DNA repair complex GO:1990391
A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
1 O60341 (/IDA)
DNA repair complex GO:1990391
A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
1 Q6ZQ88 (/ISO)