The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 42: hepatocyte nuclear factor 3-beta

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 42 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
9 P23512 (/IDA) P32182 (/IDA) P32183 (/IDA) P35582 (/IDA) P35583 (/IDA) P55318 (/IDA) P55318 (/IDA) P55318 (/IDA) Q9Y261 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
9 P23512 (/IDA) P32182 (/IDA) P33205 (/IDA) P35582 (/IDA) P35583 (/IDA) P35584 (/IDA) Q07342 (/IDA) Q17381 (/IDA) Q91765 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
7 P32315 (/NAS) P32315 (/NAS) P33205 (/NAS) P33206 (/NAS) P84961 (/NAS) Q6LD29 (/NAS) Q6LD29 (/NAS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
6 P32183 (/IDA) P35582 (/IDA) P35583 (/IDA) P35584 (/IDA) P55317 (/IDA) Q9Y261 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
6 P32315 (/NAS) P32315 (/NAS) P33206 (/NAS) P84961 (/NAS) Q6LD29 (/NAS) Q6LD29 (/NAS)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 P55317 (/ISA) P55318 (/ISA) P55318 (/ISA) P55318 (/ISA) Q9Y261 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 P55317 (/ISM) P55318 (/ISM) P55318 (/ISM) P55318 (/ISM) Q9Y261 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
5 P55317 (/NAS) P55318 (/NAS) P55318 (/NAS) P55318 (/NAS) Q9Y261 (/NAS)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
5 P32183 (/TAS) P55317 (/TAS) P55318 (/TAS) P55318 (/TAS) P55318 (/TAS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
5 P33206 (/ISS) P84961 (/ISS) Q6P839 (/ISS) Q7T1R4 (/ISS) Q7T1R4 (/ISS)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
4 O73783 (/IDA) Q07342 (/IDA) Q6P0C9 (/IDA) Q800Q3 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P23512 (/IDA) P32182 (/IDA) P35582 (/IDA) P35583 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
4 P55318 (/IMP) P55318 (/IMP) P55318 (/IMP) Q9Y261 (/IMP)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 P14734 (/IDA) P14734 (/IDA) P35583 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
3 P35582 (/ISO) P35583 (/ISO) P35584 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
3 P35582 (/ISO) P35583 (/ISO) P35584 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P32182 (/IPI) P35583 (/IPI) P55317 (/IPI)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
3 P35582 (/ISO) P35583 (/ISO) P35584 (/ISO)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
2 P14734 (/IDA) P14734 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
2 P32182 (/IDA) Q9Y261 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 P35582 (/ISO) P35583 (/ISO)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
2 P23512 (/IDA) P32182 (/IDA)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
2 P35582 (/ISO) P35583 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 P35582 (/ISO) P35583 (/ISO)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 P35583 (/ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P35584 (/IC)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q17381 (/IMP)
Core promoter sequence-specific DNA binding GO:0001046
Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
1 O73843 (/IDA)
Core promoter binding GO:0001047
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 P35583 (/TAS)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P55317 (/ISS)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P32183 (/TAS)
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
1 P35583 (/IGI)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P32182 (/IMP)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 P23512 (/IPI)
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
1 P35582 (/ISO)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 P32182 (/IPI)
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
1 P35583 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P23512 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P35582 (/ISO)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 P55317 (/IDA)
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
1 P32182 (/IDA)
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
1 P35583 (/ISO)

There are 168 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
12 P14734 (/IDA) P14734 (/IDA) P23512 (/IDA) P32182 (/IDA) P32183 (/IDA) P35582 (/IDA) P35583 (/IDA) P55317 (/IDA) P55318 (/IDA) P55318 (/IDA)
(2 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
7 P32315 (/NAS) P32315 (/NAS) P33205 (/NAS) P33206 (/NAS) P84961 (/NAS) Q6LD29 (/NAS) Q6LD29 (/NAS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
7 D2HNY8 (/ISS) E2RNQ6 (/ISS) P32182 (/ISS) P84961 (/ISS) Q7T1R4 (/ISS) Q7T1R4 (/ISS) Q9Y261 (/ISS)
Axial mesoderm morphogenesis GO:0048319
The process in which the anatomical structures of the axial mesoderm are generated and organized.
7 B3DGF9 (/IGI) O73778 (/IGI) O73783 (/IGI) Q07342 (/IGI) Q1LV18 (/IGI) Q6P0C9 (/IGI) Q800Q3 (/IGI)
Cellular glucose homeostasis GO:0001678
A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
4 P32183 (/TAS) P55318 (/TAS) P55318 (/TAS) P55318 (/TAS)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
4 P14734 (/IMP) P14734 (/IMP) P35582 (/IMP) P35584 (/IMP)
Floor plate development GO:0033504
The progression of the floor plate over time from its initial formation until its mature state.
4 B3DGF9 (/IMP) O73778 (/IMP) Q07342 (/IMP) Q1LV18 (/IMP)
Positive regulation of embryonic development GO:0040019
Any process that activates or increases the frequency, rate or extent of embryonic development.
4 D2HNY8 (/ISS) E2RNQ6 (/ISS) P32182 (/ISS) Q9Y261 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
4 P32182 (/IMP) P35583 (/IMP) P55317 (/IMP) Q17381 (/IMP)
Primitive streak formation GO:0090009
The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis.
4 D2HNY8 (/ISS) E2RNQ6 (/ISS) P32182 (/ISS) Q9Y261 (/ISS)
Positive regulation of gastrulation GO:2000543
Any process that activates or increases the frequency, rate or extent of gastrulation.
4 D2HNY8 (/ISS) E2RNQ6 (/ISS) P32182 (/ISS) Q9Y261 (/ISS)
Mesoderm formation GO:0001707
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
3 P84961 (/ISS) Q7T1R4 (/ISS) Q7T1R4 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
3 P32182 (/IDA) P32183 (/IDA) P35583 (/IDA)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
3 B3DGF9 (/IGI) O73778 (/IGI) Q1LV18 (/IGI)
Neural plate anterior/posterior regionalization GO:0021999
The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.
3 B3DGF9 (/IGI) O73778 (/IGI) Q1LV18 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P35582 (/IGI) P35583 (/IGI) P35584 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 P35582 (/ISO) P35583 (/ISO) P35584 (/ISO)
Axial mesoderm morphogenesis GO:0048319
The process in which the anatomical structures of the axial mesoderm are generated and organized.
3 B3DGF9 (/IMP) O73778 (/IMP) Q1LV18 (/IMP)
Hatching gland development GO:0048785
The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process.
3 B3DGF9 (/IMP) O73778 (/IMP) Q1LV18 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P14734 (/TAS) P14734 (/TAS)
Endoderm formation GO:0001706
The formation of the endoderm during gastrulation.
2 P14734 (/TAS) P14734 (/TAS)
Mesoderm formation GO:0001707
The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.
2 P33205 (/IMP) Q91765 (/IMP)
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
2 P32182 (/ISS) Q9Y261 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
2 P35583 (/ISO) P35584 (/ISO)
Notch signaling pathway GO:0007219
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P35582 (/IDA) P35583 (/IDA)
Salivary gland development GO:0007431
The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
2 P14734 (/IMP) P14734 (/IMP)
Salivary gland development GO:0007431
The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
2 P14734 (/NAS) P14734 (/NAS)
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
2 P14734 (/IMP) P14734 (/IMP)
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
2 P14734 (/TAS) P14734 (/TAS)
Ectodermal digestive tract development GO:0007439
The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm.
2 P14734 (/TAS) P14734 (/TAS)
Malpighian tubule morphogenesis GO:0007443
The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut.
2 P14734 (/IMP) P14734 (/IMP)
Malpighian tubule morphogenesis GO:0007443
The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut.
2 P14734 (/TAS) P14734 (/TAS)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
2 P32182 (/ISS) Q9Y261 (/ISS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P35582 (/IGI) P35583 (/IGI)
Negative regulation of epithelial to mesenchymal transition GO:0010719
Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
2 P55317 (/IMP) Q9Y261 (/IMP)
Negative regulation of epithelial to mesenchymal transition GO:0010719
Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
2 P35582 (/ISO) P35583 (/ISO)
Dorsal/ventral neural tube patterning GO:0021904
The process in which the neural tube is regionalized in the dorsoventral axis.
2 P35582 (/IGI) P35583 (/IGI)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
2 P14734 (/IMP) P14734 (/IMP)
Lung development GO:0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
2 P35582 (/IGI) P35583 (/IGI)
Ecdysone-mediated induction of salivary gland cell autophagic cell death GO:0035072
Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis.
2 P14734 (/IDA) P14734 (/IDA)
Negative regulation of multicellular organism growth GO:0040015
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.
2 P14734 (/IMP) P14734 (/IMP)
DNA endoreduplication GO:0042023
Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes.
2 P14734 (/IMP) P14734 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P14734 (/IMP) P14734 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P14734 (/TAS) P14734 (/TAS)
Negative regulation of programmed cell death GO:0043069
Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
2 P14734 (/IDA) P14734 (/IDA)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
2 P35582 (/IGI) P35583 (/IGI)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
2 P35582 (/IMP) P35583 (/IMP)
Positive regulation of smoothened signaling pathway GO:0045880
Any process that activates or increases the frequency, rate or extent of smoothened signaling.
2 P35582 (/IGI) P35583 (/IGI)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 P33206 (/ISS) Q6P839 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q91765 (/IDA) Q9Y261 (/IDA)
Anatomical structure formation involved in morphogenesis GO:0048646
The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
2 P35582 (/IGI) P35583 (/IGI)
Neuron fate specification GO:0048665
The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
2 P35582 (/IGI) P35583 (/IGI)
Epithelial tube branching involved in lung morphogenesis GO:0060441
The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
2 P35582 (/IGI) P35583 (/IGI)
Lung epithelial cell differentiation GO:0060487
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung.
2 P35582 (/IGI) P35583 (/IGI)
Neuroendocrine cell differentiation GO:0061101
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance.
2 P14734 (/IMP) P14734 (/IMP)
Connective tissue development GO:0061448
The progression of a connective tissue over time, from its formation to the mature structure.
2 P35582 (/IGI) P35583 (/IGI)
Response to interleukin-6 GO:0070741
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
2 P35583 (/TAS) Q9Y261 (/TAS)
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
2 P32182 (/ISS) Q9Y261 (/ISS)
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
2 P55317 (/TAS) Q9Y261 (/TAS)
Positive regulation of cell-cell adhesion mediated by cadherin GO:2000049
Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin.
2 P55317 (/IC) Q9Y261 (/IC)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P23512 (/IGI)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P35582 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P35582 (/ISO)
Positive regulation of transcription from RNA polymerase II promoter by glucose GO:0000432
Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter.
1 P35583 (/IDA)
Positive regulation of transcription from RNA polymerase II promoter by glucose GO:0000432
Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter.
1 Q9Y261 (/ISS)
Cellular glucose homeostasis GO:0001678
A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.
1 P35584 (/IMP)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 P35583 (/IMP)
Ectoderm formation GO:0001705
The formation of ectoderm during gastrulation.
1 P35583 (/IGI)
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
1 P35583 (/IDA)
Neural plate development GO:0001840
The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.
1 P33205 (/IMP)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 P35582 (/IDA)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 P55317 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P35584 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9Y261 (/IDA)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P35583 (/ISO)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 P35584 (/IMP)
Pattern specification process GO:0007389
Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
1 P35583 (/IGI)
Ventral midline development GO:0007418
The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate.
1 Q07342 (/IMP)
Endoderm development GO:0007492
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
1 Q07342 (/IGI)
Endoderm development GO:0007492
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
1 Q07342 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P32183 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P35584 (/ISO)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q17381 (/IGI)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
1 P35583 (/IMP)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 P35584 (/IMP)
Anatomical structure morphogenesis GO:0009653
The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
1 P35583 (/IGI)
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
1 P33205 (/IMP)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
1 P35583 (/IGI)
Dorsal/ventral pattern formation GO:0009953
The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.
1 P35583 (/IGI)
Positive regulation of macroautophagy GO:0016239
Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.
1 Q17381 (/IMP)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
1 P35583 (/IDA)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
1 P35583 (/IMP)
Regulation of steroid metabolic process GO:0019218
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.
1 P35583 (/IDA)
Regulation of steroid metabolic process GO:0019218
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.
1 P35583 (/IMP)
Cell differentiation in hindbrain GO:0021533
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
1 P35583 (/IGI)
Cell differentiation in hindbrain GO:0021533
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.
1 P35583 (/IMP)
Oligodendrocyte cell fate commitment GO:0021779
The process in which the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte.
1 Q07342 (/IMP)
Dorsal/ventral neural tube patterning GO:0021904
The process in which the neural tube is regionalized in the dorsoventral axis.
1 P35583 (/IDA)
Signal transduction involved in regulation of gene expression GO:0023019
Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.
1 P35583 (/IDA)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
1 Q17381 (/IMP)
Regulation of blood coagulation GO:0030193
Any process that modulates the frequency, rate or extent of blood coagulation.
1 Q9Y261 (/IDA)
Regulation of blood coagulation GO:0030193
Any process that modulates the frequency, rate or extent of blood coagulation.
1 P35583 (/ISO)
Forebrain development GO:0030900
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
1 P33205 (/IMP)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
1 Q9Y261 (/IDA)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
1 P35583 (/IMP)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
1 P35583 (/ISO)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
1 P35584 (/TAS)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
1 P32183 (/IEP)
Central nervous system myelin formation GO:0032289
The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.
1 Q07342 (/IMP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P55317 (/IDA)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P35582 (/ISO)
Somite rostral/caudal axis specification GO:0032525
The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary.
1 P35583 (/IMP)
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P32182 (/IEP)
Negative regulation of glucokinase activity GO:0033132
Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.
1 P35583 (/IDA)
Negative regulation of glucokinase activity GO:0033132
Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.
1 Q9Y261 (/ISS)
Positive regulation of intracellular estrogen receptor signaling pathway GO:0033148
Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
1 P55317 (/IMP)
Positive regulation of intracellular estrogen receptor signaling pathway GO:0033148
Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
1 P35582 (/ISO)
Tube morphogenesis GO:0035239
The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
1 P35582 (/IMP)
Positive regulation of embryonic development GO:0040019
Any process that activates or increases the frequency, rate or extent of embryonic development.
1 P35583 (/IMP)
Hormone metabolic process GO:0042445
The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
1 P35582 (/IMP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 P35582 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 P55317 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 P35582 (/ISO)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q9Y261 (/IMP)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 P35583 (/ISO)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
1 P35583 (/IGI)
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 Q17381 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 P33205 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P35583 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 P35583 (/ISO)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
1 P55317 (/IMP)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
1 P35582 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q9Y261 (/TAS)
Positive regulation of transcription by RNA polymerase III GO:0045945
Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III.
1 P35583 (/IMP)
Mesendoderm development GO:0048382
The process whose specific outcome is the progression of the mesendoderm over time, from its formation to the mature structure. In animal embryos, mesendoderm development gives rise to both mesoderm and endoderm tissues.
1 P35583 (/IMP)
Cell development GO:0048468
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
1 P35583 (/IMP)
Embryonic morphogenesis GO:0048598
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
1 Q17381 (/IMP)
Neuron fate specification GO:0048665
The process in which a cell becomes capable of differentiating autonomously into a neuron in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.
1 P35583 (/IMP)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 P55317 (/IMP)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 P35582 (/ISO)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 P35582 (/IDA)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 P35582 (/IMP)
Lung morphogenesis GO:0060425
The process in which the anatomical structures of the lung are generated and organized.
1 P35582 (/IMP)
Pharynx development GO:0060465
The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth.
1 Q17381 (/IGI)
Pharynx development GO:0060465
The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth.
1 Q17381 (/IMP)
Secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528
The process in which a relatively unspecialized epithelial cell acquires specialized features of a secretory columnal luminar epithelial cell of the prostate.
1 P35582 (/IMP)
Cell fate specification involved in pattern specification GO:0060573
The process involved in the specification of the identity of a cell in a field of cells that is being instructed as to how to differentiate. Once specification has taken place, that cell will be committed to differentiate down a specific pathway if left in its normal environment.
1 Q17381 (/IMP)
Epithelial-mesenchymal signaling involved in prostate gland development GO:0060738
Any process that results in the transfer of information from an epithelial cell to a mesenchymal cell where it is interpreted and contributes to the progression of the prostate gland over time.
1 P35582 (/IGI)
Prostate gland epithelium morphogenesis GO:0060740
The process in which the anatomical structures of epithelia of the prostate gland are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
1 P35582 (/IMP)
Prostate gland stromal morphogenesis GO:0060741
The process in which the prostate gland stroma is generated and organized. The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland.
1 P35582 (/IMP)
Epithelial cell maturation involved in prostate gland development GO:0060743
The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell of the prostate gland to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.
1 P35582 (/IMP)
Alveolar secondary septum development GO:0061144
The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule.
1 P35582 (/IMP)
Regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
1 P35583 (/IDA)
Regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
1 Q9Y261 (/ISS)
Response to caloric restriction GO:0061771
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caloric restriction, insufficient food energy intake.
1 Q17381 (/IDA)
Negative regulation of transcription from RNA polymerase II promoter by glucose GO:0061987
Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter.
1 P35583 (/IDA)
Negative regulation of transcription from RNA polymerase II promoter by glucose GO:0061987
Any process involving glucose that decreases the frequency, rate or extent or transcription from an RNA polymerase II promoter.
1 Q9Y261 (/ISS)
Positive regulation of hepatocyte differentiation GO:0070368
Any process that activates or increases the rate or extent of hepatocyte differentiation.
1 P32183 (/IMP)
Positive regulation of hepatocyte differentiation GO:0070368
Any process that activates or increases the rate or extent of hepatocyte differentiation.
1 P35584 (/ISO)
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
1 Q9Y261 (/IGI)
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
1 P35583 (/IMP)
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
1 P35583 (/ISO)
Primitive streak formation GO:0090009
The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis.
1 P35583 (/IMP)
Respiratory basal cell differentiation GO:1902691
The process in which a relatively unspecialized cell acquires the specialized features of a respiratory basal cell.
1 P35582 (/IMP)
Response to sodium arsenite GO:1903935
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus.
1 Q17381 (/IMP)
Positive regulation of gastrulation GO:2000543
Any process that activates or increases the frequency, rate or extent of gastrulation.
1 P35583 (/IMP)
Negative regulation of detection of glucose GO:2000971
Any process that stops, prevents or reduces the frequency, rate or extent of detection of glucose.
1 P35583 (/IDA)
Negative regulation of detection of glucose GO:2000971
Any process that stops, prevents or reduces the frequency, rate or extent of detection of glucose.
1 Q9Y261 (/ISS)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
14 B3DGF9 (/IDA) O73778 (/IDA) P14734 (/IDA) P14734 (/IDA) P23512 (/IDA) P32182 (/IDA) P32183 (/IDA) P35582 (/IDA) P35583 (/IDA) P35584 (/IDA)
(4 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
9 A0A024R0R3 (/IDA) A0A024R0R3 (/IDA) A0A024R0R3 (/IDA) B0ZTD4 (/IDA) P55317 (/IDA) P55318 (/IDA) P55318 (/IDA) P55318 (/IDA) Q9Y261 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 P32315 (/NAS) P32315 (/NAS) P33205 (/NAS) P33206 (/NAS) P84961 (/NAS) Q6LD29 (/NAS) Q6LD29 (/NAS)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
6 A0A024R0R3 (/IDA) A0A024R0R3 (/IDA) A0A024R0R3 (/IDA) P55318 (/IDA) P55318 (/IDA) P55318 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P35582 (/ISO) P35583 (/ISO) P35584 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q7T1R4 (/ISS) Q7T1R4 (/ISS) Q91765 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P55318 (/TAS) P55318 (/TAS) P55318 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 P35582 (/ISO) P35583 (/ISO) P35584 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P33205 (/IC) Q91765 (/IC)
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
2 P14734 (/IDA) P14734 (/IDA)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
2 B0ZTD4 (/IDA) Q9Y261 (/IDA)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
1 P55317 (/IDA)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
1 P35582 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P55317 (/TAS)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
1 P35583 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P35584 (/TAS)
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
1 P35582 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 P35584 (/ISO)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
1 P35583 (/ISO)