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CATH Superfamily 1.10.10.10

Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 410: ADA regulatory protein, putative

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Methylated-DNA-[protein]-cysteine S-methyltransferase activity GO:0003908
Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.
 24 O76339 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA)
(14 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
 23 P06134 (/TAS) P06134 (/TAS) P06134 (/TAS) P06134 (/TAS) P06134 (/TAS) P06134 (/TAS) P06134 (/TAS) P06134 (/TAS) P06134 (/TAS) P06134 (/TAS)
(13 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 23 P06134 (/IPI) P06134 (/IPI) P06134 (/IPI) P06134 (/IPI) P06134 (/IPI) P06134 (/IPI) P06134 (/IPI) P06134 (/IPI) P06134 (/IPI) P06134 (/IPI)
(13 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
 23 P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA)
(13 more)
Damaged DNA binding GO:0003684
Interacting selectively and non-covalently with damaged DNA.
 2 Q2HQK2 (/IDA) Q9U1Y0 (/IDA)
Transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0016765
Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor).
 2 Q2HQK2 (/IDA) Q9U1Y0 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
 1 Q5LNA1 (/ISS)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
 26 O76339 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA)
(16 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
 23 P06134 (/IEP) P06134 (/IEP) P06134 (/IEP) P06134 (/IEP) P06134 (/IEP) P06134 (/IEP) P06134 (/IEP) P06134 (/IEP) P06134 (/IEP) P06134 (/IEP)
(13 more)
Peptidyl-cysteine methylation GO:0018125
The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine.
 23 P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA)
(13 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 23 P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA)
(13 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
 23 P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA)
(13 more)
DNA demethylation GO:0080111
The removal of a methyl group from one or more nucleotides within an DNA molecule.
 23 P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA) P06134 (/IDA)
(13 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
 1 Q5LNA1 (/ISS)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 2 Q2HQK2 (/IC) Q9U1Y0 (/IC)