The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 176: transcription factor ETV6 isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
11 P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI)
(1 more)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
10 P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
10 P41212 (/ISA) P41212 (/ISA) P41212 (/ISA) P41212 (/ISA) P41212 (/ISA) P41212 (/ISA) P41212 (/ISA) P41212 (/ISA) P41212 (/ISA) P41212 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
10 P41212 (/ISM) P41212 (/ISM) P41212 (/ISM) P41212 (/ISM) P41212 (/ISM) P41212 (/ISM) P41212 (/ISM) P41212 (/ISM) P41212 (/ISM) P41212 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
10 P41212 (/NAS) P41212 (/NAS) P41212 (/NAS) P41212 (/NAS) P41212 (/NAS) P41212 (/NAS) P41212 (/NAS) P41212 (/NAS) P41212 (/NAS) P41212 (/NAS)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
10 P41212 (/IC) P41212 (/IC) P41212 (/IC) P41212 (/IC) P41212 (/IC) P41212 (/IC) P41212 (/IC) P41212 (/IC) P41212 (/IC) P41212 (/IC)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
10 P41212 (/TAS) P41212 (/TAS) P41212 (/TAS) P41212 (/TAS) P41212 (/TAS) P41212 (/TAS) P41212 (/TAS) P41212 (/TAS) P41212 (/TAS) P41212 (/TAS)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
10 P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI) P41212 (/IPI)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 P97360 (/ISO)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 P97360 (/IDA)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 P97360 (/IDA)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
1 P97360 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 P97360 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P97360 (/ISO)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
10 P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA) P41212 (/IDA)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
10 P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP)
Hematopoietic stem cell proliferation GO:0071425
The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.
10 P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP) P41212 (/IMP)
Embryonic hemopoiesis GO:0035162
The stages of blood cell formation that take place within the embryo.
3 B2GTA2 (/IMP) Q7ZU22 (/IMP) Q90ZS9 (/IMP)
Hematopoietic stem cell proliferation GO:0071425
The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.
3 P97360 (/ISS) Q0VC65 (/ISS) Q0VC65 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 P97360 (/ISO)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 P97360 (/IDA)
Vitellogenesis GO:0007296
The production of yolk. Yolk is a mixture of materials used for embryonic nutrition.
1 P97360 (/IMP)
Neurogenesis GO:0022008
Generation of cells within the nervous system.
1 P97360 (/IMP)
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
1 P97360 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P97360 (/IDA)
Hematopoietic stem cell proliferation GO:0071425
The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.
1 P97360 (/ISO)
Mesenchymal cell apoptotic process GO:0097152
Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.
1 P97360 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
20 A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA)
(10 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
20 A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA) A0A0S2Z3C9 (/IDA)
(10 more)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 P97360 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P97360 (/ISO)