CATH Classification

Domain Context

CATH Clusters

Superfamily Ubiquinol cytochrome reductase, transmembrane domain
Functional Family Cytochrome b-c1 complex subunit Rieske, mitochondrial

Enzyme Information
Quinol--cytochrome-c reductase.
based on mapping to UniProt P08067
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2).
-!- The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. -!- It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. -!- The mammalian enzyme contains cytochromes b-562, b-566 and c(1), and a 2-iron ferredoxin. -!- Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC -!- Formerly EC

UniProtKB Entries (1)

Saccharomyces cerevisiae S288C
Cytochrome c oxidase subunit 3

PDB Structure

External Links
Primary Citation
Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1.
Hartley, A.M., Lukoyanova, N., Zhang, Y., Cabrera-Orefice, A., Arnold, S., Meunier, B., Pinotsis, N., Marechal, A.
Nat. Struct. Mol. Biol.