CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family cAMP-dependent protein kinase catalytic subunit alpha

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P05132
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P05132
KAPCA_MOUSE
Mus musculus
CAMP-dependent protein kinase catalytic subunit alpha

PDB Structure

PDB 6E21
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex.
Gerlits, O., Weiss, K.L., Blakeley, M.P., Veglia, G., Taylor, S.S., Kovalevsky, A.
Sci Adv