CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.10 | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Domain Context
CATH Clusters
| Superfamily | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
| Functional Family | N(4)-bis(aminopropyl)spermidine synthase |
Enzyme Information
| 2.5.1.128 |
N(4)-bis(aminopropyl)spermidine synthase.
based on mapping to UniProt Q5JIZ3
2 S-adenosyl 3-(methylthio)propylamine + spermidine = 2 S-methyl- 5'-thioadenosine + N(4)-bis(aminopropyl)spermidine.
-!- The enzyme, characterized from the thermophilic archaeon Thermococcus kodakarensis, synthesizes the branched-chain polyamine N(4)- bis(aminopropyl)spermidine, which is required for cell growth at high-temperature. -!- When spermine is used as substrate, the enzyme forms N(4)- aminopropylspermine.
|
UniProtKB Entries (1)
| Q5JIZ3 |
BPSA_THEKO
Thermococcus kodakarensis KOD1
N(4)-bis(aminopropyl)spermidine synthase
|
PDB Structure
| PDB | 5XNH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine.
FEBS J.
|