CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.640 | Aspartate Aminotransferase; domain 2 |
|
3.40.640.10 | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
Domain Context
CATH Clusters
| Superfamily | Type I PLP-dependent aspartate aminotransferase-like (Major domain) |
| Functional Family |
Enzyme Information
| 2.5.1.73 |
O-phospho-L-seryl-tRNA:Cys-tRNA synthase.
based on mapping to UniProt Q59072
O-phospho-L-seryl-tRNA(Cys) + sulfide = L-cysteinyl-tRNA(Cys) + phosphate.
-!- In organisms like Archaeoglobus fulgidus lacking EC 6.1.1.16 for the direct Cys-tRNA(Cys) formation, Cys-tRNA(Cys) is produced by an indirect pathway, in which EC 6.1.1.27 ligates O-phosphoserine to tRNA(Cys), and EC 2.5.1.73 converts the produced O-phospho-L-seryl- tRNA(Cys) to Cys-tRNA(Cys). -!- The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism. -!- Methanosarcina mazei can use both pathways, the direct route using EC 6.1.1.16 and the indirect pathway with EC 6.1.1.27 and EC 2.5.1.73. -!- Formerly EC 2.5.1.n3.
|
UniProtKB Entries (1)
| Q59072 |
SPSS_METJA
Methanocaldococcus jannaschii DSM 2661
O-phospho-L-seryl-tRNA:Cys-tRNA synthase
|
PDB Structure
| PDB | 5X6B |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for tRNA-dependent cysteine biosynthesis
Nat Commun
|