CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Wee1-like kinase 2

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P0C1S8
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P0C1S8
WEE2_HUMAN
Homo sapiens
Wee1-like protein kinase 2

PDB Structure

PDB 5VDK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.
Zhu, J.Y., Cuellar, R.A., Berndt, N., Lee, H.E., Olesen, S.H., Martin, M.P., Jensen, J.T., Georg, G.I., Schonbrunn, E.
J. Med. Chem.