CATH Domain 5tpaA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.190	D-Maltodextrin-Binding Protein; domain 2
	3.40.190.10	Periplasmic binding protein-like II

Domain Context

CATH Clusters

Superfamily	Periplasmic binding protein-like II
Functional Family	Putative glutamate receptor ionotropic NMDA 2B

Enzyme Information

UniProtKB Entries (1)

NMDE1_HUMAN

Homo sapiens

Glutamate receptor ionotropic, NMDA 2A

PDB Structure

PDB	5TPA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. Villemure, E., Volgraf, M., Jiang, Y., Wu, G., Ly, C.Q., Yuen, P.W., Lu, A., Luo, X., Liu, M., Zhang, S., Lupardus, P.J., Wallweber, H.J., Liederer, B.M., Deshmukh, G., Plise, E., Tay, S., Wang, T.M., Hanson, J.E., Hackos, D.H., Scearce-Levie, K., Schwarz, J.B., Sellers, B.D. ACS Med Chem Lett