CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Interleukin-1 receptor-associated kinase 4

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q9NWZ3
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9NWZ3
IRAK4_HUMAN
Homo sapiens
Interleukin-1 receptor-associated kinase 4

PDB Structure

PDB 5T1S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation.
Smith, G.F., Altman, M.D., Andresen, B., Baker, J., Brubaker, J.D., Chen, H., Chen, Y., Childers, M., Donofrio, A., Ferguson, H., Fischer, C., Fischmann, T.O., Gibeau, C., Hicks, A., Jin, S., Kattar, S., Kleinschek, M.A., Leccese, E., Lesburg, C., Li, C., Lim, J., Liu, D., Maclean, J.K.F., Mansoor, F., Moy, L.Y., Mulrooney, E.F., Necheva, A.S., Presland, J., Rakhilina, L., Yang, R., Torres, L., Zhang-Hoover, J., Northrup, A.
Bioorg. Med. Chem. Lett.