CATH Classification

Domain Context

CATH Clusters

Superfamily Bromodomain-like
Functional Family Histone acetyltransferase p300

Enzyme Information

2.3.1.48
Histone acetyltransferase.
based on mapping to UniProt Q92793
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.

UniProtKB Entries (1)

Q92793
CBP_HUMAN
Homo sapiens
CREB-binding protein

PDB Structure

PDB 5MPK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
Zhu, J., Dong, J., Batiste, L., Unzue, A., Dolbois, A., Pascanu, V., Sledz, P., Nevado, C., Caflisch, A.
ACS Med Chem Lett