CATH Domain 5j3hE02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.220	Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2
	2.10.220.10	Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2

Domain Context

CATH Clusters

Superfamily	Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
Functional Family	Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P06213

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06213

INSR_HUMAN

Homo sapiens

Insulin receptor

PDB Structure

PDB	5J3H
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor. Lawrence, C.F., Margetts, M.B., Menting, J.G., Smith, N.A., Smith, B.J., Ward, C.W., Lawrence, M.C. J.Biol.Chem.