CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.79.20
Functional Family NADH pyrophosphatase

Enzyme Information

3.6.1.22
NAD(+) diphosphatase.
based on mapping to UniProt P32664
NAD(H) + H(2)O = AMP + NMN(H).
-!- This enzyme, described from plants, animals, and bacteria, can act on both reduced and oxidized forms of its substrate, although enzymes from different organisms have different preferences. -!- Also acts on other dinucleotides, including NADP(H), FAD(H(2)), and the thionicotinamide analogs of NAD(+) and NADP(+).

UniProtKB Entries (1)

P32664
NUDC_ECOLI
Escherichia coli K-12
NADH pyrophosphatase

PDB Structure

PDB 5ISY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of prokaryotic NAD-RNA decapping by NudC
Zhang, D., Liu, Y., Wang, Q., Guan, Z., Wang, J., Liu, J., Zou, T., Yin, P.
Cell Res.