CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.40 | Beta Barrel | |
2.40.70 | Cathepsin D, subunit A; domain 1 | |
2.40.70.10 | Acid Proteases |
Domain Context
CATH Clusters
Superfamily | Acid Proteases |
Functional Family | Beta-secretase 1 |
Enzyme Information
3.4.23.46 |
Memapsin 2.
based on mapping to UniProt P56817
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
-!- Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. -!- Belongs to peptidase family A1.
|
UniProtKB Entries (1)
P56817 |
BACE1_HUMAN
Homo sapiens
Beta-secretase 1
|
PDB Structure
PDB | 5HDZ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure-Based Design of an Iminoheterocyclic beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central A beta in Nonhuman Primates.
J.Med.Chem.
|