CATH Classification

Domain Context

CATH Clusters

Superfamily Topoisomerase I, domain 2
Functional Family DNA topoisomerase

Enzyme Information

5.6.2.2
DNA topoisomerase.
based on mapping to UniProt O95985
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.

UniProtKB Entries (1)

Q9H7E2
TDRD3_HUMAN
Homo sapiens
Tudor domain-containing protein 3

PDB Structure

PDB 5GVE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of the interaction between Topoisomerase III beta and the TDRD3 auxiliary factor
Goto-Ito, S., Yamagata, A., Takahashi, T.S., Sato, Y., Fukai, S.
Sci Rep