CATH Domain 5guvA04

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.120	DNA Methylase; Chain A, domain 2
	3.90.120.10	DNA Methylase, subunit A, domain 2

Superfamily	DNA Methylase, subunit A, domain 2
Functional Family	DNA (cytosine-5)-methyltransferase

2.1.1.37

DNA (cytosine-5-)-methyltransferase.

based on mapping to UniProt P13864

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

-!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/ -!- Formerly EC 2.1.1.73.

DNMT1_MOUSE

Mus musculus

DNA (cytosine-5)-methyltransferase 1

PDB	5GUV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1. Ye, F., Kong, X.Q., Zhang, H., Liu, Y., Shao, Z., Jin, J., Cai, Y., Zhang, R., Li, L., Zhang, Y.W., Liu, Y.C., Zhang, C., Xie, W., Yu, K., Ding, H., Zhao, K., Chen, S., Jiang, H., Baylin, S.B., Luo, C. ACS Chem. Biol.