CATH Classification

Domain Context

CATH Clusters

Superfamily Nitric Oxide Synthase; Chain A, domain 3
Functional Family Nitric oxide synthase, brain

Enzyme Information
Nitric-oxide synthase (flavodoxin).
based on mapping to UniProt O34453
2 L-arginine + 3 reduced flavodoxin + 4 O(2) = 2 L-citrulline + 2 nitric oxide + 3 oxidized flavodoxin + 4 H(2)O.
-!- The enzyme, found in bacteria and archaea, consist of only an oxygenase domain and functions together with bacterial ferredoxins or flavodoxins. -!- The orthologous enzymes from plants and animals also contain a reductase domain and use only NADPH as the electron donor (cf. EC -!- Formerly EC

UniProtKB Entries (1)

Bacillus subtilis subsp. subtilis str. 168
Nitric oxide synthase oxygenase

PDB Structure

PDB 5G68
External Links
Primary Citation
Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-Based Inhibitors.
Holden, J.K., Lewis, M.C., Cinelli, M.A., Abdullatif, Z., Pensa, A.V., Silverman, R.B., Poulos, T.L.