CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.238.210
Functional Family Glutaminase kidney isoform, mitochondrial

Enzyme Information

3.5.1.2
Glutaminase.
based on mapping to UniProt O94925
L-glutamine + H(2)O = L-glutamate + NH(3).

UniProtKB Entries (1)

O94925
GLSK_HUMAN
Homo sapiens
Glutaminase kidney isoform, mitochondrial

PDB Structure

PDB 5FI6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design and evaluation of novel glutaminase inhibitors.
McDermott, L.A., Iyer, P., Vernetti, L., Rimer, S., Sun, J., Boby, M., Yang, T., Fioravanti, M., O'Neill, J., Wang, L., Drakes, D., Katt, W., Huang, Q., Cerione, R.
Bioorg.Med.Chem.