CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1310.20
Functional Family

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt P03132
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

P03132
REP68_AAV2S
Adeno-associated virus 2 Srivastava/1982
Protein Rep68

PDB Structure

PDB 5DCX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Studies of AAV2 Rep68 Reveal a Partially Structured Linker and Compact Domain Conformation.
Musayev, F.N., Zarate-Perez, F., Bardelli, M., Bishop, C., Saniev, E.F., Linden, R.M., Henckaerts, E., Escalante, C.R.
Biochemistry