CATH Classification
Domain Context
CATH Clusters
Superfamily | Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 |
Functional Family | Tyrosine-protein kinase receptor |
Enzyme Information
2.7.10.1 |
Receptor protein-tyrosine kinase.
based on mapping to UniProt P06213
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.
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UniProtKB Entries (1)
P06213 |
INSR_HUMAN
Homo sapiens
Insulin receptor
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PDB Structure
PDB | 4ZXB |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.
Structure
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