CATH Classification

Domain Context

CATH Clusters

Superfamily Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2
Functional Family Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P06213
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06213
INSR_HUMAN
Homo sapiens
Insulin receptor

PDB Structure

PDB 4ZXB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.
Croll, T.I., Smith, B.J., Margetts, M.B., Whittaker, J., Weiss, M.A., Ward, C.W., Lawrence, M.C.
Structure