CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.490 | Globin-like |
|
1.10.490.10 | Globins |
Domain Context
CATH Clusters
| Superfamily | Globins |
| Functional Family | Diguanylate cyclase DosC |
Enzyme Information
| 2.7.7.65 |
Diguanylate cyclase.
based on mapping to UniProt P0AA89
2 GTP = 2 diphosphate + cyclic di-3',5'-guanylate.
-!- Can be activated by BeF3, a phosphoryl mimic, which results in dimerization. -!- Dimerization is required but is not sufficient for diguanylate- cyclase activity. -!- Cyclic di-3',5'-guanylate is an intracellular signaling molecule that controls motility and adhesion in bacterial cells; it was first identified as having a positive allosteric effect on EC 2.4.1.12.
|
UniProtKB Entries (1)
| P0AA89 |
DOSC_ECOLI
Escherichia coli K-12
Diguanylate cyclase DosC
|
PDB Structure
| PDB | 4ZVB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural analysis of an oxygen-regulated diguanylate cyclase.
Acta Crystallogr.,Sect.D
|
