CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.750 | Elongin C; Chain C, domain 1 | |
1.10.750.10 | von Hippel-Lindau disease tumour suppressor, alpha domain |
Domain Context
CATH Clusters
Superfamily | von Hippel-Lindau disease tumour suppressor, alpha domain |
Functional Family | von Hippel-Lindau disease tumor suppressor |
Enzyme Information
UniProtKB Entries (1)
P40337 |
VHL_HUMAN
Homo sapiens
Von Hippel-Lindau disease tumor suppressor
|
PDB Structure
PDB | 4W9L |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
J.Med.Chem.
|