CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.60 | Sandwich | |
2.60.40 | Immunoglobulin-like | |
2.60.40.780 | von Hippel-Lindau disease tumour suppressor, beta domain |
Domain Context
CATH Clusters
Superfamily | von Hippel-Lindau disease tumour suppressor, beta domain |
Functional Family | von Hippel-Lindau disease tumor suppressor |
Enzyme Information
UniProtKB Entries (1)
Q15370 |
ELOB_HUMAN
Homo sapiens
Elongin-B
|
PDB Structure
PDB | 4W9J |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
J.Med.Chem.
|