CATH Classification

Domain Context

CATH Clusters

Superfamily von Hippel-Lindau disease tumour suppressor, beta domain
Functional Family von Hippel-Lindau disease tumor suppressor

Enzyme Information

UniProtKB Entries (1)

Q15370
ELOB_HUMAN
Homo sapiens
Elongin-B

PDB Structure

PDB 4W9J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities.
Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli, A.
J.Med.Chem.