CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Maternal embryonic leucine zipper kinase

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q14680
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q14680
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q14680
MELK_HUMAN
Homo sapiens
Maternal embryonic leucine zipper kinase

PDB Structure

PDB 4UMU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.
Johnson, C.N., Adelinet, C., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Calo, F., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., Mevellec, L., Mcmenamin, R., Pasquier, E., Patel, S., Rees, D.C., Linders, J.T.M.
Acs Med.Chem.Lett.