CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P25911
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P25911
LYN_MOUSE
Mus musculus
Tyrosine-protein kinase Lyn

PDB Structure

PDB 4TZI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity.
Jin, L.L., Wybenga-Groot, L.E., Tong, J., Taylor, P., Minden, M.D., Trudel, S., McGlade, C.J., Moran, M.F.
Mol.Cell Proteomics