CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Vitamin B12 import ATP-binding protein BtuD

Enzyme Information

7.6.2.8
ABC-type vitamin B12 transporter.
based on mapping to UniProt P06611
ATP + H(2)O + vitamin B12-[cobalamin-binding protein](Side 1) = ADP + phosphate + vitamin B12(Side 2) + [cobalamin-binding protein](Side 1).
-!- An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. -!- Does not undergo phosphorylation during the transport process. -!- A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of cobalamin derivatives. -!- Formerly EC 3.6.3.33.

UniProtKB Entries (1)

P06609
BTUC_ECOLI
Escherichia coli K-12
Vitamin B12 import system permease protein BtuC

PDB Structure

PDB 4R9U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of AMP-PNP-bound BtuCD and mechanism of ATP-powered vitamin B12 transport by BtuCD-F.
Korkhov, V.M., Mireku, S.A., Veprintsev, D.B., Locher, K.P.
Nat.Struct.Mol.Biol.