CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase

Enzyme Information

2.1.1.235
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase.
based on mapping to UniProt P95748
2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-alpha-D- glucopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,6- dideoxy-alpha-D-glucopyranose.
-!- The enzyme is involved in the biosynthesis of mycaminose, an essential structural component of the macrolide antibiotic tylosin, which is produced by the bacterium Streptomyces fradiae.

UniProtKB Entries (1)

P95748
TYLM1_STRFR
Streptomyces fradiae
DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase

PDB Structure

PDB 4OQD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Production of a novel N-monomethylated dideoxysugar.
Thoden, J.B., Holden, H.M.
Biochemistry