CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family Neuraminidase 3

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt Q9Y3R4
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

Q9Y3R4
NEUR2_HUMAN
Homo sapiens
Sialidase-2

PDB Structure

PDB 4NCS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Tuning mechanism-based inactivators of neuraminidases: mechanistic and structural insights.
Buchini, S., Gallat, F.X., Greig, I.R., Kim, J.H., Wakatsuki, S., Chavas, L.M., Withers, S.G.
Angew.Chem.Int.Ed.Engl.