CATH Domain 4k88A03

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.110	Translation Initiation Factor IF3
	3.30.110.30	C-terminal domain of ProRS

Domain Context

CATH Clusters

Superfamily	C-terminal domain of ProRS
Functional Family	Bifunctional glutamate/proline--tRNA ligase

Enzyme Information

6.1.1.15	Proline--tRNA ligase. based on mapping to UniProt P07814 ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).
6.1.1.17	Glutamate--tRNA ligase. based on mapping to UniProt P07814 ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

UniProtKB Entries (1)

SYEP_HUMAN

Homo sapiens

Bifunctional glutamate/proline--tRNA ligase

PDB Structure

PDB	4K88
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone. Son, J., Lee, E.H., Park, M., Kim, J.H., Kim, J., Kim, S., Jeon, Y.H., Hwang, K.Y. Acta Crystallogr.,Sect.D