CATH Domain 4hu4B00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.450	EAL domain

Domain Context

CATH Clusters

Superfamily	EAL domain
Functional Family	Cyclic di-GMP phosphodiesterase yahA

Enzyme Information

3.1.4.52

Cyclic-guanylate-specific phosphodiesterase.

based on mapping to UniProt P76129

Cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine.

-!- Inhibited by Ca(2+) and Zn(2+). -!- Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and an allosteric activator of EC 2.4.1.12 rendering it inactive. -!- It is the balance between these two enzymes that determines the cellular level of cyclic di-3',5'-guanylate.

UniProtKB Entries (1)

P76129

DOSP_ECOLI

Escherichia coli K-12

Oxygen sensor protein DosP

PDB Structure

PDB	4HU4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structures of the catalytic EAL domain of the Escherichia coli direct oxygen sensor. Tarnawski, M., Barends, T.R., Hartmann, E., Schlichting, I. Acta Crystallogr.,Sect.D

Network disruptions