CATH Classification
Level | CATH Code | Description |
---|---|---|
6 | Special | |
6.20 | Other non-globular | |
6.20.320 | YefM-like fold | |
6.20.320.10 |
Domain Context
CATH Clusters
Superfamily | 6.20.320.10 |
Functional Family |
Enzyme Information
2.4.2.- |
Pentosyltransferases.
based on mapping to UniProt Q9H2K2
|
2.4.2.30 |
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt Q9H2K2
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
|
UniProtKB Entries (1)
Q9H2K2 |
TNKS2_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase tankyrase-2
|
PDB Structure
PDB | 4HLK |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Screening and structural analysis of flavones inhibiting tankyrases.
J.Med.Chem.
|