CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma

Enzyme Information

3.1.4.11
Phosphoinositide phospholipase C.
based on mapping to UniProt P19174
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
-!- These enzymes form some of the cyclic phosphate Ins(cyclic 1,2)P(4,5)P(2) as well as Ins(1,4,5)P(3). -!- They show activity toward phosphatidylinositol, i.e., the activity of EC 4.6.1.13 in vitro at high calcium concentration.

UniProtKB Entries (1)

P19174
PLCG1_HUMAN
Homo sapiens
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

PDB Structure

PDB 4FBN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation.
Bunney, T.D., Esposito, D., Mas-Droux, C., Lamber, E., Baxendale, R.W., Martins, M., Cole, A., Svergun, D., Driscoll, P.C., Katan, M.
Structure