CATH Domain 4dnlA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.150	C2 domain

Domain Context

CATH Clusters

Superfamily	C2 domain
Functional Family	Kinase C alpha type

Enzyme Information

2.7.11.13

Protein kinase C.

based on mapping to UniProt P17252

ATP + a protein = ADP + a phosphoprotein.

-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P17252

KPCA_HUMAN

Homo sapiens

Protein kinase C alpha type

PDB Structure

PDB	4DNL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of a C2 domain of a protein kinase C alpha (PRKCA) from Homo sapiens at 1.90 A resolution Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) To be published

Network disruptions