CATH Classification

Domain Context

CATH Clusters

Superfamily Topoisomerase I, domain 2
Functional Family DNA topoisomerase 3-alpha

Enzyme Information

5.6.2.2
DNA topoisomerase.
based on mapping to UniProt Q13472
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- These enzymes bring about the conversion of one topological isomer of DNA into another, e.g., the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences, cf. EC 5.6.2.3. -!- Formerly EC 5.99.1.2.

UniProtKB Entries (1)

Q13472
TOP3A_HUMAN
Homo sapiens
DNA topoisomerase 3-alpha

PDB Structure

PDB 4CHT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Mechanistic Insight Into Holliday-Junction Dissolution by Topoisomerase Iiialpha and Rmi1
Bocquet, N., Bizard, A.H., Abdulrahman, W., Larsen, N.B., Faty, M., Cavadini, S., Bunker, R.D., Kowalczykowski, S.C., Cejka, P., Hickson, I.D., Thoma, N.H.
Nat.Struct.Mol.Biol.