CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Eukaryotic initiation factor 4A-III

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt P38919
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

Q9HCG8
CWC22_HUMAN
Homo sapiens
Pre-mRNA-splicing factor CWC22 homolog

PDB Structure

PDB 4C9B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of the Human Eif4Aiii-Cwc22 Complex Shows How a Dead-Box Protein is Inhibited by a Mif4G Domain
Buchwald, G., Schuessler, S., Basquin, C., Le Hir, H., Conti, E.
Proc.Natl.Acad.Sci.USA