CATH Domain 4b4cA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.60	Homeodomain-like

Domain Context

CATH Clusters

Superfamily	Homeodomain-like
Functional Family	Chromodomain-helicase-DNA-binding protein 2 isoform 1

Enzyme Information

3.6.4.12

DNA helicase.

based on mapping to UniProt O14646

ATP + H(2)O = ADP + phosphate.

-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

O14646

CHD1_HUMAN

Homo sapiens

Chromodomain-helicase-DNA-binding protein 1

PDB Structure

PDB	4B4C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure of the DNA-Binding Domain of Human Chd1. Allerston, C.K., Cooper, C.D.O., Shrestha, L., Vollmar, M., Burgess-Brown, N., Yue, W.W., Carpenter, E.P., Arrowsmith, C.H., Edwards, A., Bountra, C., von Delft, F., Gileadi, O. To be Published

Network disruptions