1 keywords

CATH Domain 4a6eA01

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.10 Arc Repressor Mutant, subunit A
Homologous Superfamily 1.10.10.10 Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family Acetylserotonin O-methyltransferase

Enzyme Information

2.1.1.4
Acetylserotonin O-methyltransferase.
based on mapping to UniProt P46597
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin.
-!- Some other hydroxyindoles also act as acceptor, more slowly.

UniProtKB Entries (1)

P46597
ASMT_HUMAN
Homo sapiens
Acetylserotonin O-methyltransferase

PDB Structure

PDB 4A6E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure and Functional Mapping of Human Asmt, the Last Enzyme of the Melatonin Synthesis Pathway.
Botros, H.G., Legrand, P., Pagan, C., Bondet, V., Weber, P., Ben-Abdallah, M., Lemiere, N., Huguet, G., Bellalou, J., Maronde, E., Beguin, P., Haouz, A., Shepard, W., Bourgeron, T.
J.Pineal Res.