CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family Lanosterol 14-alpha-demethylase

Enzyme Information

UniProtKB Entries (1)

Q385E8
Q385E8_TRYB2
Trypanosoma brucei brucei TREU927
Lanosterol 14-alpha-demethylase

PDB Structure

PDB 3TIK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Pharmacological characterization, structural studies, and in vivo activities of anti-chagas disease lead compounds derived from tipifarnib.
Buckner, F.S., Bahia, M.T., Suryadevara, P.K., White, K.L., Shackleford, D.M., Chennamaneni, N.K., Hulverson, M.A., Laydbak, J.U., Chatelain, E., Scandale, I., Verlinde, C.L., Charman, S.A., Lepesheva, G.I., Gelb, M.H.
Antimicrob.Agents Chemother.