CATH Classification

Domain Context

CATH Clusters

Superfamily 3.20.20.210
Functional Family

Enzyme Information

2.1.1.14
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
based on mapping to UniProt Q8CWX6
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine.
-!- Requires phosphate. -!- The enzyme from Escherichia coli also requires a reducing system. -!- Unlike EC 2.1.1.13 this enzyme does not contain cobalamin.

UniProtKB Entries (1)

Q8CWX6
METE_STRMU
Streptococcus mutans UA159
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

PDB Structure

PDB 3T0C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Cobalamin-Independent Methionine Synthase (MetE) from Streptococcus mutans: A Dynamic Zinc-Inversion Model
Fu, T.M., Almqvist, J., Liang, Y.H., Li, L., Huang, Y., Su, X.D.
J.Mol.Biol.