CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.565 | Heat Shock Protein 90 | |
3.30.565.10 | Histidine kinase-like ATPase, C-terminal domain |
Domain Context
CATH Clusters
Superfamily | Histidine kinase-like ATPase, C-terminal domain |
Functional Family | Heat shock protein HSP 90-alpha |
Enzyme Information
UniProtKB Entries (1)
P07900 |
HS90A_HUMAN
Homo sapiens
Heat shock protein HSP 90-alpha
|
PDB Structure
PDB | 3R4O |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.
J.Med.Chem.
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