CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Dihydrofolate reductase

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P22906
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P22906
DYR_CANAX
Candida albicans
Dihydrofolate reductase

PDB Structure

PDB 3QLW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Candida albicans Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal the Flexibility of Active Site Loop Residues Critical for Ligand Potency and Selectivity.
Paulsen, J.L., Bendel, S.D., Anderson, A.C.
Chem.Biol.Drug Des.